尼可地尔预防桡动脉痉挛的临床观察  

Clinical observation of preventive effect of Nicorandil on radial artery spasm

作　　者：宋涛[1] 熊岗[2] 姚园[1] SONG Tao XIONG Gang YAO Yuan(Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Chin)

机构地区：[1]武汉大学人民医院心内科,湖北省武汉市430060 [2]武汉亚洲心脏病医院心内科,湖北省武汉市430060

出　　处：《中国心血管病研究》2016年第9期830-833,共4页Chinese Journal of Cardiovascular Research

基　　金：湖北省自然科学基金（项目编号：2014CFB209）

摘　　要：目的 探讨应用尼可地尔预防冠状动脉造影（CAG）时桡动脉痉挛（RAS）的可行性和价值.方法 选择2015年1～12月期间经桡动脉行CAG检查的患者450例,随机分为对照组、硝酸甘油组和尼可地尔组,观察记录三组患者的一般情况、伴随疾病、穿刺次数、血肿、RAS及药物不良反应等情况.结果 尼可地尔组和硝酸甘油组患者的RAS发生率分别为9.3％和8.0％,均明显低于对照组患者的24.0％,且差异均有统计学意义（P＜0.05）.三组患者在体重、年龄、伴随疾病、一针穿刺成功率等方面比较未见统计学差异（P＞0.05）.结论 口服尼可地尔可以有效减少桡动脉痉挛的发生,且无严重不良反应,安全有效.Objective To observe the value and security of Nicorandil in preventing radial artery spasm （RAS） which happened through transradial coronary angiography （CAG）. Methods 450 patients underwent CAG were selected and divided into 3 groups randomly： Nieorandil group, Nitroglycerin group and control group, each group included 150 cases. Characteristics and coneominant diseases of the cases, complications such as RAS were observed in three groups. Results The incidences of RAS in Nicorandil group and Nitroglycerin group were 9.3% and 8.0%, which were both significantly lower（P〈0.05 ） than that in control group（24.0% ）. There was no significant difference among three groups in other clinical baseline data. Conclusion Oral Nieorandil can reduce RAS incidenee significantly without any severe affeet.

关 键 词：冠状动脉造影 尼可地尔 桡动脉痉挛 

分 类 号：R541.4[医药卫生—心血管疾病]