Brown adipose tissue and its therapeutic application  

作　　者：Xiaoxue Yuan Meng Dong Hyuek Jong Lee Wanzhu Jin 

机构地区：[1]Key Laboratory of Animal Ecology and Conservation Biology,Institute of Zoology, Chinese Academy of Sciences,Beijing 100101, China [2]The University of the Chinese Academy of Sciences,Beijing 100049, China

出　　处：《Science Bulletin》2016年第19期1498-1503,共6页科学通报（英文版）

摘　　要：In addition to white adipose tissue （WAT） that stores energy, human and small mammals also have brown adipose tissue （BAT） that dissipates chemical energy for thermogenesis. BAT contains multilocular lipid droplets and much higher numbers of mitochondria than WAT. The mitochondria in BAT uncouple large amounts of fuel oxidation from ATP for heat generation. Accumulating evidences have demonstrated that increased activity and/or amount of BAT can reverse obesity and improve insulin resistance, which highlights that BAT plays an important role in energy metabolism. In this review, we summarized recent findings that shows advantageous effects of BAT activation in metabolic diseases. In addition, we presented the function and role of brown and beige fat cells and regulatory factors for them. Finally, we discussed the potential application of brown adipocytes-based therapy and pharmacological intervention to increase BAT activity for the treatment of obesity and related diseases including insulin resistance, cardiovascular diseases and type 2 diabetes.除了存储精力的白脂肪质的织物(WAT ) ，人、小的哺乳动物也有为生热作用浪费化学能的棕色的脂肪质的织物(蝙蝠) 。蝙蝠比 WAT 包含 multilocular 类脂化合物微滴和线粒体的高得多的数字。在蝙蝠的线粒体解开从为热产生的 ATP 的大量燃料氧化。积累的证据表明了蝙蝠罐头颠倒肥胖的那项增加的活动或数量并且改进胰岛素抵抗，它加亮那只蝙蝠在精力起一个重要作用新陈代谢。在这评论，我们总结了在新陈代谢的疾病显示出蝙蝠激活的有益的效果的最近的调查结果。另外，我们为他们介绍了棕色、米黄色的胖房间和规章的因素的功能和角色。最后，我们讨论了棕色的基于 adipocytes 的治疗和药理学干预的潜在的申请包括胰岛素抵抗，心血管的疾病和类型为肥胖和相关疾病的处理增加蝙蝠活动 2 糖尿病。

关 键 词：Brown adipose tissue LIPIDMETABOLISM Therapeutic application 

分 类 号：Q578[生物学—生物化学] S826[农业科学—畜牧学]