2型糖尿病肾病患者代谢指标变化研究  

Analysis of the metabolic index in type 2 diabetic nephropathy patients

作　　者：欧红芹[1] 祖磊[1] 邹玲梅[1] 金强[1] OU Hong-qing ZU Lei ZOU Ling-mei JIN Qiang(Department of Endocrinology, The Third People＇s Hospital of Bengbu, Bengbu Anhui 233000, Chin)

机构地区：[1]安徽省蚌埠市第三人民医院内分泌科,233000

出　　处：《蚌埠医学院学报》2016年第9期1158-1160,共3页Journal of Bengbu Medical College

摘　　要：目的：分析2型糖尿病并发肾病患者代谢指标,探讨2型糖尿病肾病发病的代谢紊乱特点Hb A1c。方法：收集131例住院2型糖尿病患者的临床资料,根据尿肾功能检查分为2型糖尿病无肾病并发症组（T2DM组）54例与2型糖尿病并发肾病组（DKD组）77例,根据血尿酸水平再将DKD组分为高尿酸组和正常尿酸组,分别检测其糖化血红蛋白（Hb A1c）、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）、血尿酸及血肌酐等指标。结果：DKD组患者血清TC、LDL-C、肌酐及尿酸水平均高于T2DM组（P〈0.05~P〈0.01）,而HDL-C水平低于T2DM组（P〈0.05）。与正常尿酸组比较,高尿酸组的TC、LDL-C及肌酐水平均升高（P〈0.05~P〈0.01）,而HDL-C水平明显较低（P〈0.01）,但2组患者Hb A1c差异无统计学意义（P〉0.05）。结论：糖尿病肾病的发生与血糖、血脂及尿酸的代谢紊乱有关,积极控制糖尿病患者的血糖、血脂与尿酸的水平对防治糖尿病肾病具有重要临床意义。Objective：To analyze the metabolic disorders index in patients with type 2 diabetes mellitus complicated with kidney disease, and explore the characteristics of metabolic disorders in type 2 diabetic nephropathy patients. Methods：The clinical data of 131 cases with type 2 diabetes were analyzed,and the patients were type 2 diabetes complicated without kidney disease（T2DM group） and type 2 diabetes mellitus complicated with kidney disease group（ DKD group） according to the urine and kidney function. The levels of the glycosylated hemoglobin （ HbA1 e ） , total cholesterol （ TC ） , triglyeeride （ TG ） , low density lipoprotein cholesterol （ LDL-C ） , high density lipoprotein cholesterol（HDL-C） ,blood uric acid and ereatinine in two groups were detected and analyzed. Seventy-seven DKD patients were divided into the high uric acid group and normal uric acid group according to the level of uric acid, and the levels of glycosylated hemoglobin, blood lipid and creatinine between two groups were compared. Results： The levels of the serum TC, LDL-C, creatinine and uric acid in patients with type 2 diabetic nephropathy group were significantly higher than those in patients without kidney disease （P 〈 0.01 ）, but the level of HDL-C level was lower than that in control group （ P 〈 0.05 ）. Among the type 2 diabetic nephropathy patients, the levels of TC, LDL-C, and creatinine in high uric acid group were significantly higher than those in normal uric acid（P 〈 0.01 ）, but the level of HDL-C was significantly lower（ P 〈 0.05 ）, and the difference of the level of HbAlc between two groups was statistically significant （ P 〉 0. 05 ）. Conclusions ： The occurrence of diabetic nephropathy is associated with the metabolic disorder of blood sugar, blood lipids and uric acid. The active controling the levels of the blood sugar, blood lipids and uric acid of patients with diabetes has important clinical significance in preventing and treating diabetic nephropathy.

关 键 词：糖尿病并发症 尿酸 血脂 

分 类 号：R587.2[医药卫生—内分泌]