慢性持续期哮喘患儿血清IL-17、TGF-β1水平变化及临床意义  

Serum levels of IL-17 and TGF-β1 in children with chronic persistent asthma,and its clinical significance

作　　者：刘小群[1] 陈啸洪[1] 张佩红[1] 李华浚[1] LIU Xiao-qun CHEN Xiao-hong ZHANG Pei-hong LI Hua-jun(Department of Paediatrics, The People＇s Hospital of Shaoxing, Shaoxing Zhejiang 312000, China)

机构地区：[1]浙江省绍兴市人民医院(浙江大学绍兴医院)小儿内科,312000

出　　处：《蚌埠医学院学报》2016年第9期1178-1180,共3页Journal of Bengbu Medical College

基　　金：浙江省绍兴市科技计划项目(2012B70069)

摘　　要：目的:探讨慢性持续期哮喘患儿血清白细胞介素-17(IL-17)、转化生长因子-β1(TGF-β1)的水平变化及临床意义。方法:90例慢性持续期哮喘患儿,按病情分为轻度组(n=56)和中重度组(n=34),30名健康儿童作为对照组,用肺功能检查、ELISA法分别检测3组小儿第1秒用力呼气容积占预计值百分比及血清IL-17、TGF-β1水平。结果:轻度组、中重度组患儿血清IL-17水平分别为(103.44±7.20)pg/mL和(147.31±4.42)pg/mL,均显著高于对照组的(67.43±3.49)pg/mL(P<0.01);轻度组、中重度组患儿血清TGF-β1水平分别为(55.58±8.46)pg/mL和(80.26±4.62)pg/mL,亦均显著高于对照组的(32.61±6.45)pg/mL(P<0.01);患儿血清IL-17、TGF-β1的水平与第1秒用力呼气容积占预计值百分比均呈负相关关系(P<0.01)。血清IL-17与TGF-β1呈正相关关系(P<0.01)。结论:慢性持续期哮喘患儿存在血IL-17、TGF-β1水平的改变,且与病情密切相关,IL-17、TGF-β1参与了支气管哮喘的发病机制。Objective： To investigate the serum levels of interleukin-17 （IL-17） and transforming growth factor-β1 （TGF-β1） in children with chronic persistent asthma, and its clinical significance. Methods：Ninety children with chronic asthma were divided into the mild group （56 cases） and moderate severe group（ 34 cases） according to the disease condition, and 30 healthy children were set as the control group. The FEVI% and serum levels of IL-17 and TGF-131 in 3 groups were detected by pulmonary function test and ELISA, respectively. Results：The serum levels of IL-17 in the mild group and moderate severe group were （ 103.44 ：t： 7.20）pg/mL and （ 147.31 ± 4.42 ）pg/mL, which was significantly higher than that in control group （67.43 ± 3.49）pg/mL（ P 〈 0.01 ）. The serum levels of TGF-β1 in mild group and moderate severe group were （ 55.58 ± 8.46 ） pg/mL and （ 80. 26 ± 4. 62 ） pg/mL, which was significantly higher than that in control group（ 32.61 ± 6.45 ） pg/mL（ P 〈 0.01 ）. The serum levels of IL- 17 and TGF-131 were negatively correlated with FEVI% （ P 〈 0.01 ）, and the level of IL-17 was positively correlated with TGF-131 （ P 〈 0. 01 ）. Conclusions： The chronic persistent asthma can lead to the changes of the IL-17 and TGF-β1 levels, which is closely related to the disease condition, and the TGF-β1 and IL-17 involve in the pathogenesis of bronchial asthma.

关 键 词：哮喘 白细胞介素-17 转化生长因子-Β1 儿童 慢性持续期 

分 类 号：R562.25[医药卫生—呼吸系统]