丹参多酚酸盐对急性心梗PCI术患者氧化应激与血管内皮功能的影响  

Effects of salvianolate on oxidative stress and vascular endothelial function in patients with acute myocardial infarction by treatment of PCI

作　　者：吴德旭[1] 朱君[1] 蔡文渊[1] 王广艳[1] 腾名子[1] 

机构地区：[1]江苏省无锡市第三人民医院心内科,江苏无锡214000

出　　处：《实用临床医药杂志》2016年第19期16-19,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨丹参多酚酸盐对急性心梗经皮冠状动脉介入术(PCI)患者氧化应激与血管内皮功能的影响。方法选取急性心肌梗死伴随阿司匹林抵抗患者88例,均行PCI术治疗,采用随机数表法将患者分为对照组和观察组各44例。2组术前均口服氯吡格雷、阿司匹林,对照组术后给予心肌梗死二级预防治疗,观察组在对照组基础上应用丹参多酚酸盐。用药7 d后检测丙二醛(MDA)、超氧化物歧化酶(SOD)、血浆内皮素-1(ET-1)、一氧化氮(NO)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB),测定左室射血分数(LVEF),记录治疗期间出血及药物副作用;术后电话和门诊随访6个月,记录2组心血管事件及PCI术后再狭窄发生情况。结果观察组治疗后MDA、ET-1、CK、CK-MB显著低于对照组,SOD、FMD、NO、LVEF显著高于对照组(P<0.05);观察组住院及随访期间心血管事件、术后再狭窄率显著低于对照组(P<0.05)。结论丹参多酚酸盐可改善急性心急梗死患者PCI术后氧化应激反应、血管内皮功能相关指标,保护心肌,改善疾病预后。Objective To investigate the effects of salvianolate on oxidative stress and vascular endothelial function in patients with acute myocardial infarction by percutaneous coronary intervention（ PCI）. Methods A total of 88 patients with acute myocardial infarction complicated with aspirin resistance were selected. All patients were treated with PCI. The patients were randomly divided into control group and observation group,44 cases in each group. Before operation,both groups were given clopidogrel and aspirin orally. After operation,the control group was given secondary prevention of acute myocardial infarction. On the basis,the observation group was treated with salvianolate at 30 min before operation and 7 days after operation. After 7 days of medication,malondialdehyde（ MDA）,superoxide dismutase（ SOD）,plasma endothelin-1（ ET-1）,nitric oxide（ NO）,creatine kinase（ CK）,creatine kinase isoenzyme（ CK-MB） and left ventricular ejection fraction（ LVEF） were detected.Bleeding and side effects during the treatment were recorded. After operation,the patients were followed up for 6 months. The incidence rates of cardiovascular events and restenosis after PCI were recorded. Results After treatment,MDA,ET-1,CK and CK-MB in the observation group were significantly lower than those in the control group,while SOD,FMD,NO and LVEF were significantly higher than those in the control group（ P〈0. 05）. The incidence rates of cardiovascular events and restenosis after operation in the observation group were significantly lower than those in the control group（ P〈0. 05）. Conclusion Salvianolate can improve the oxidative stress and vascular endothelial function related indexes in patients with acute myocardial infarction after PCI,protect myocardium and improve the prognosis.

关 键 词：急性心肌梗死 介入治疗 血管内皮功能 氧化应激 疗效 

分 类 号：R542.2[医药卫生—心血管疾病]