缬沙坦在丁酮-异丙醚混合溶剂中溶解度测定及关联  

Measurement and correlation of the solubility of valsartan in butanone-isopropyl ether mixed solvents

作　　者：王清清[1] 孙勤[1] 杨阿三[1] 程榕[1] 郑燕萍[1] 

机构地区：[1]浙江工业大学化学工程学院,浙江杭州310014

出　　处：《化学工程》2016年第10期37-41,共5页Chemical Engineering(China)

摘　　要：溶解度数据对结晶动力学研究及结晶器优化起到重要作用,利用静态平衡法测定了缬沙坦在丁酮-异丙醚混合溶剂中278.15—323.15 K的溶解度。结果表明:缬沙坦在混合溶剂中的溶解度,随着温度和丁酮摩尔分数的变大而变大,随着异丙醚摩尔分数的变大而变小。采用Modified Apelblat、一般多项式和hybrid方程对溶解度数据进行关联,平均相对偏差分别为0.95%,0.25%,3.64%,其中一般多项式方程关联较好。用van't Hoff分析计算了缬沙坦在溶解过程中的热力学参数(焓变、熵变和吉布斯自由能),表明溶解过程为自发吸热熵驱动过程。The solubility data had important effects on the crystallization kinetics and the optimization of the crystallizer. The solubility of valsartan in butanone-isopropyl ether mixed solvents was measured at 278.15 -323.15 K by a static balance method. The results show that the mole fraction solubility of valsartan increases with an increase in temperature and an enrichment in butanone content, while decreases with increasing the mole fraction of isopropyl ether. The solubility data are regressed and correlated by the modified Apelblat equation, the general single equation, and the hybrid equation. The mean deviation values of these three models are 0.95%, 0.25%, and 3. 64%, respectively. Therefore, the general single equation is the best choice in the correlation of the solubility data of valsartan in butanone-isopropyl ether mixed solvents. In addition, the thermodynamic studies （including the Gibbs energy, entropy, and enthalpy） were calculated by van＇t Hoff analysis. The results show that the dissolution of valsartan in mixed solvents is endothermic, spontaneous, and entropy-driven.

关 键 词：缬沙坦 丁酮 异丙醚 溶解度 关联 

分 类 号：TQ460.1[化学工程—制药化工]