激素联合来氟米特、环磷酰胺治疗狼疮肾炎疗效研究  

Study on the Effect of Hormone Combined With Leflunomide and Cyclophosphamide in the Treatment of Lupus Nephritis

作　　者：王满响[1] 

机构地区：[1]江苏省沭阳县人民医院风湿科,江苏沭阳223600

出　　处：《中国继续医学教育》2016年第28期156-158,共3页China Continuing Medical Education

摘　　要：目的 观察研究激素联合来氟米特、环磷酰胺治疗狼疮肾炎的临床疗效。方法 选取我院2014年7月-2016年7月收治的76例狼疮肾炎患者作为研究对象,将所有患者随机均分为实验组与对照组,每组各38例。实验组患者采用激素联合来氟米特及环磷酰胺治疗,而对照组则采用激素联合来氟米特治疗,治疗结束后比较两组患者的临床疗效及不良反应情况。结果 经治疗,实验组患者治疗总有效率为92.11%（35/38）,高于对照组76.32%（29/38）,两组对比,差异具有统计学意义（P〈0.05）。实验组患者不良反应发生率为13.16%（5/38）,低于对照组28.95%（11/38）,两组比较,差异具有统计学意义（P〈0.05）。结论 治疗狼疮肾炎患者时,采用激素联合来氟米特及环磷酰胺治疗效果比激素单独联合来氟米特更好,安全性更高。Objective To observe the clinical effect of hormone combined with lelfunomide and cyclophosphamide in the treatment of lupus nephritis. Methods From July 2014 to July 2016 in our hospital, 76 cases of lupus nephritis patients as the research object, all patients were randomly divided into experimental group and control group, 38 cases in each group. Patients in the experimental group were treated with hormone combined with lelfunomide and cyclophosphamide, while the control group was treated with hormone combination therapy. The clinical efficacy and adverse reaction of two groups were compared after the treatment.Results After treatment, the treatment group of patients with the total effective rate was 92.11% （35/38）, significantly higher than those in control group 76.32% （29/38）, and the difference was statistically significant （P 〈 0.05）. Patients in the experimental group the incidence of adverse reaction was 13.16% （5/38）, was significantly lower than that of control group were 28.95% （11/38）, and the difference was statistically significant （P 〈 0.05）. Conclusion In the treatment of patients with lupus nephritis, the effect hormone combined with leflunomide and cyclophosphamide was better than lelfunomide combined with hormone, higher security.

关 键 词：狼疮肾炎 来氟米特 环磷酰胺 激素 

分 类 号：R593.2[医药卫生—内科学]