不同联合用药方法治疗顽固性高血压的临床疗效及安全性  

Clinical Efficacy and Safety of Different Combination of Drugs in the Treatment of Resistant Hypertension

作　　者：吴沁原 万镇[2] 

机构地区：[1]江苏省建湖县第三人民医院内科,江苏建湖224700 [2]江苏省建湖县人民医院心内科,江苏建湖224700

出　　处：《中国继续医学教育》2016年第29期163-165,共3页China Continuing Medical Education

摘　　要：目的探讨不同联合用药方案治疗顽固性高血压的临床疗效及安全性。方法筛选我院收治的顽固性高血压患者150例作为研究对象。随机分为A、B、C组,每组50例,其中A组单纯应用硝苯地平控释片(拜新同)治疗,B组采用拜新同联合厄贝沙坦氢氯噻嗪片(依仑平),C组应用拜新同联合琥珀酸美托洛尔缓释片(倍他乐克),比较三组治疗效果及药物不良反应发生情况。结果 B、C组治疗总有效率、血压控制效果均优于A组(P<0.05),并且B组治疗总有效率、血压控制效果优于C组(P<0.05);三组均未发生严重不良反应,不良反应发生率比较差异无统计学意义(P>0.05)。结论拜新同联合依仑平可获得良好的血压控制效果以及药物治疗效果,并且安全性较高。Objective To explore the clinical effcacy and safety of different combination schemes in treatment of refractory hypertension.Methods150 cases of patients with refractory hypertension in our hospital were taken as the research object and randomly divided into A, B, C group, 50 cases in each group, the A group was treated with Nifedipine Controlled Release Tablets （Adalat）, group B was treated with Adalat combined with Irbesartan and Hydrochlorothiazide Tablets, C group was treated with Adalat combined with Metoprolol Succinate Sustained-release Tablets（Betaloc）, the occurrence of adverse reactions and drug treatment effects were compared between the three groups.Results The total effective rate, the blood pressure control in B, C group were signiifcantly better than that of A Group （P〈0.05）, and the total effective rate of B group, the blood pressure control effect were better than that of C group （P〈0.05）. There were no serious adverse reactions in the three groups, and there was no signiifcant difference in the incidence of adverse reactions （P〉0.05）.ConclusionThe effect of good blood pressure control and drug treatment can be obtained by the combination of Adalat and Yi Lunping, and have high safety.

关 键 词：硝苯地平控释片 厄贝沙坦氢氯噻嗪 琥珀酸美托洛尔缓释片 顽固性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]