注射用炎琥宁雾化吸入辅助治疗小儿呼吸系统感染的系统评价  

Aerosol Inhalation of Yanhuning for Injection in the Adjuvant Treatment of Children Respiratory System Infections:A Systematic Review

作　　者：刘慧敏[1] 李鹏[1] 朱雪松[1] 陈富超[1] 李春雷[1] 王林海[2] 

机构地区：[1]湖北医药学院附属东风医院药学部,湖北十堰442008 [2]湖北医药学院附属人民医院药学部,湖北十堰442008

出　　处：《中国药房》2016年第30期4245-4248,共4页China Pharmacy

基　　金：十堰市科学技术研究与开发项目(No.16Y48)

摘　　要：目的:系统评价注射用炎琥宁雾化吸入辅助治疗小儿呼吸系统感染的疗效与安全性,为临床超说明书用药的给药方式提供循证证据。方法:计算机检索Pub Med、Science direct、EMBase、中国医院知识总库期刊全文数据库、中文科技期刊全文数据库、万方数据库,纳入注射用炎琥宁雾化吸入辅助治疗小儿呼吸系统感染的随机对照试验(RCT)或半随机对照试验(q RCT),提取资料并进行质量评价后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入11项研究,合计982例患儿。Meta分析结果显示,注射用炎琥宁雾化吸入辅助治疗小儿呼吸系统感染可以显著提高患儿的总有效率[OR=4.47,95%CI(2.80,7.16),P<0.001],缩短气喘消失时间[MD=-2.05,95%CI(-2.86,-1.24),P<0.001]、咳嗽消失时间[MD=-1.73,95%CI(-2.34,-1.13),P<0.001]、肺部啰音消失时间[MD=-2.13,95%CI(-3.38,-0.89),P<0.001],减少住院天数[MD=-2.38,95%CI(-2.86,-1.89),P<0.001],且不增加不良反应发生率[OR=0.65,95%CI(0.21,2.00),P=0.45],但不能缩短患儿退热时间[MD=-1.18,95%CI(-2.58,0.22),P=0.10]。结论:注射用炎琥宁雾化吸入辅助治疗小儿呼吸系统感染疗效较好,有助于改善患儿呼吸道症状、缩短住院时间,且不增加不良反应的发生。OBJECTIVE：To systematically review the efficacy and safety of the aerosol inhalation of Yanhuning for injection in adjuvant treatment of children respiratory system infections,and provide evidence-based basis for the administration way of off-label drug use in clinic. METHODS：Retrieved from Pub Med,Science direct,EMBase,CHKD,VIP and Wanfang Database,randomized controlled trials（RCT）or quasi-randomized controlled trials（q RCT）about the aerosol inhalation of Yanhuning for injection in adjuvant treatment of children respiratory system infections were collected. Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation. RESULTS：Totally 11 RCTs were enrolled,involving 982 patients.Results of Meta-analysis showed,the aerosol inhalation of Yanhuning for injection in adjuvant treatment of children respiratory system infections can significantly improve the clinical total effective rate [OR=4.47,95%CI（2.80,7.16）,P〈0.001],shorten breath shortness duration [MD=-2.05,95%CI（-2.86,-1.24）,P〈0.001],cough duration [MD=-1.73,95%CI（-2.34,-1.13）,P〈0.001] and pulmonary rales duration [MD=-2.13,95% CI（-3.38,-0.89）,P〈0.001],reduce the hospitalization days [MD=-2.38,95%CI（-2.86,-1.89）,P〈0.001],and not increase the incidence of adverse reactions [OR=0.65,95%CI（0.21,2.00）,P=0.45],nor shorten the fever duration[MD=-1.18,95%CI（-2.58,0.22）,P=0.10]. CONCLUSIONS：The aerosol inhalation of Yanhuning for injection can improve the clinical efficacy in adjuvant treatment of children respiratory system infection,it helps to improve respiratory symptoms in children and does not increase the incidence of adverse reactions.

关 键 词：注射用炎琥宁 小儿呼吸系统感染 雾化吸入 系统评价 

分 类 号：R725.6[医药卫生—儿科]