vasostatin-2在轻中度原发性高血压患者中的表达水平研究  

Changes of circulating plasma vasostatin-2 levels and its significance in patients with mild-to-moderate hypertension

作　　者：陈长源[1] 白明[1] 赵存瑞 牛欢[1] 康宏[1] 乙成成[1] 张钲[1] CHEN Changyuan BAI Ming ZHAO Cunrui NIU Huan KANG Hong YI Chengcheng ZHANG Zheng(Department of Cardiology, The First Hospital of Lanzhou University, Lanzhou, 730000, Chin)

机构地区：[1]兰州大学第一医院心脏中心,兰州730000

出　　处：《临床心血管病杂志》2016年第10期1021-1023,共3页Journal of Clinical Cardiology

基　　金：兰州大学中央高校基本科研业务费专项资金(No:lzujbky-2013-218)

摘　　要：目的:观察未经药物治疗的轻中度原发性高血压患者外周血vasostatin-2(VS-2)水平的变化并阐明其临床意义。方法:采用ELISA方法检测89例原发性高血压患者和76例正常血压对照者空腹外周血VS-2水平并比较其BMI、静息心率等指标。结果:与对照组比较,高血压组患者血浆VS-2水平升高[(0.24±0.04)pg/ml︰(0.32±0.06)pg/ml,P<0.05]。Pearson相关分析显示,平均动脉压及静息心率与VS-2水平呈正相关(r分别为0.301、0.427,均P<0.01),而年龄、BMI、血脂及空腹血糖与VS-2水平无关。多元线性回归分析显示,校正年龄、BMI、血脂、血糖等因素后,平均动脉压及静息心率是血浆VS-2水平的独立影响因子(均P<0.05)。结论:未经治疗的原发性高血压患者外周血VS-2水平升高,提示其拮抗过度激活的交感神经系统,可能在高血压病理状态下发挥心血管保护作用。Objective：To investigate the changes of circulating plasma vasostatin-2（VS-2）levels at fasting and the significance of VS-2levels in patients with untreated mild-to-moderate hypertension.Method：Plasma total VS-2levels at fasting were measured by ELISA in eighty-nine patients with untreated mild-to-moderate hypertension and seventy-six controls with normal blood pressure.BMI and heart rate（HR）were detected.Result：VS-2levels were significantly higher in hypertension group compared with control group[（0.24±0.04）pg/ml vs（0.32±0.06）pg/ml,P〈0.05）.Mean arterial pressure（MAP）and HR were positively correlated with VS-2level（r=0.301,0.427,both P〈0.01）.Age,BMI,TC,TG and glucose were not correlated with VS-2level.Multiple regression analysis showed that both MAP and HR were independent influence factors of VS-2level（both P〈0.05）.Conclusion：Circulating plasma VS-2levels increase in patients with untreated mild-to-moderate hypertension,which suggests VS-2might play aprotective role in the pathological status of hypertension by antagonizing the over-activated sympathetic nervous system.

关 键 词：vasostatin-2 嗜铬粒蛋白A 高血压 原发性 

分 类 号：R544.1[医药卫生—心血管疾病]