头孢匹胺钠与甲硝唑的配伍稳定性研究  

Study on the Compatibility of Cefpiramide Sodium and Metronidazole Injection

作　　者：张艳芬[1] ZHANG Yanfen(Tianjin Wuqing People＇s Hospital, Tianjin 301700, China)

机构地区：[1]天津市武清区人民医院,天津301700

出　　处：《中国现代应用药学》2016年第10期1307-1311,共5页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究注射用头孢匹胺钠与甲硝唑注射液的配伍稳定性。方法考察配伍前后溶液外观、不溶性微粒和p H值的变化情况;采用HPLC考察注射用头孢匹胺钠与甲硝唑注射液配伍后,在5,25,35℃,避光、室内光照、紫外线照射条件下,8 h内配伍液中头孢匹胺钠与甲硝唑的含量变化,并考察头孢匹胺钠与甲硝唑在配伍液中有关物质的限度。结果在混合4 h内,头孢匹胺钠与甲硝唑含量没有明显变化,紫外线对配伍液的稳定性有一定的影响。结论注射用头孢匹胺钠与甲硝唑注射液在4 h内可配伍使用,应尽量避免日光照射。OBJECTIVE To investigate the compatibility of cefpiramide sodium for injection and metronidazole injection. METHODS The changes in p H value, appearance and insoluble particles were observed, and the relative contents of cefpiramide sodium and metronidazole were determined by HPLC in 8 h after mix at 5, 25, 35 ℃ under the condition of dark, indoor illumination and ultraviolet light. The limits of the related substances of cefpiramide sodium and metronidazole in the compatibility solution were investigated also. RESULTS In 4 h, cefpiramide sodium and metronidazole concentration didn＇t change significantly. The ultraviolet radiation had a certain effect on the stability of the mixture. CONCLUSION Cefpiramide sodium for injection can be combined with metronidazole injection in 4 h, but should avoid sunlight.

关 键 词：注射用头孢匹胺钠 甲硝唑注射液 配伍稳定性 HPLC 有关物质 

分 类 号：R917.101[医药卫生—药物分析学]