天然黄酮类化合物防治心脑血管疾病的研究进展  

Research progress of natural flavonoids in prevention and treatment of cardiovascular and cerebrovascular diseases

作　　者：张怀民[1] 杨虹[2] 郑海洲[3] 

机构地区：[1]河北医科大学第四医院药学部,河北石家庄050011 [2]河北经贸大学生物科学与工程学院,河北石家庄050061 [3]华北制药集团新药研究开发有限责任公司,河北石家庄050015

出　　处：《中国新药与临床杂志》2016年第10期704-708,共5页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：黄酮类化合物是一类广泛存在于各种植物中的多酚化合物,生理活性广泛,毒副作用少。实验研究表明黄酮类化合物具有抗氧化、清除自由基、抗炎、调节血脂、减轻心血管损伤和抑制血小板聚集等多种生物活性和药理作用,可以有效降低心脑血管疾病发生和死亡的风险。黄酮类化合物防治心脑血管疾病的机制主要有提高超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶等抗氧化酶活力,抑制脂质过氧化,减少细胞黏附分子表达,下调炎症细胞因子和激活Nrf2/血红素加氧酶、PI3K-Akt和转录因子-κB等信号转导通路等。本文简要总结黄酮类化合物调控心脑血管系统的最新进展,为以黄酮类化合物为药效成分的新药开发和临床应用提供参考。Flavonoids are polyphenolic compounds that are ubiquitous in a variety of plants, with wide physiological activities and low toxic and side effects. According to large numbers of the findings, flavonoids had many pharmacological activities such as antioxidation, scavenging free radicals, anti-inflammatory, regulating blood lipid, reducing cardiovascular damage, inhibiting platelet aggregation and so on, which could effectively reduce the risk for cardiovascular and cerebrovascular diseases （CCVD） morbidity and mortality. Their mechanisms in preventing and treating CCVD mainly included upregulation of antioxidant enzymes such as superoxideenzyme, catalase and glutathione peroxidase, inhibition of lipid peroxidation, reduction of cell adhesion molecules, downregulation of inflammation cytokines and activation of Nrf2/heme oxygenase- 1, PI3K-Akt and nuclear factor-kappa B signal transduction pathway. This review focuses on the advance in domestic and foreign knowledge of flavonoids exerts their beneficial effects in CCVD, in order to provide reliable literature information for the further development and clinical application of flavonoids.

关 键 词：心血管疾病 脑血管障碍 黄酮类 药理作用分子作用机制 

分 类 号：R285.6[医药卫生—中药学] R972[医药卫生—中医学]