射频消融对原发性肝癌治疗评价及预后危险因素分析  

Evaluation of radiofrequency ablation in treatment of primary liver cancer and its risk factors

作　　者：陈兵[1] 吴威[2] CHEN Bing WU Wei(Department of Electrical Diagnosis ,the Sixth People＇s Hospital of Shenyang ,Shenyang 110006,China)

机构地区：[1]沈阳市第六人民医院电诊科,辽宁沈阳110006 [2]沈阳市第六人民医院外科,辽宁沈阳110006

出　　处：《实用放射学杂志》2016年第10期1545-1548,共4页Journal of Practical Radiology

摘　　要：目的：分析射频消融对原发性肝癌治疗及复发的临床治疗评价并探讨影响预后的相关危险因素。方法纳入本院肿瘤科经射频消融治疗的164例患者进行分析，研究内容包括治疗前后的肝功能、甲胎蛋白（AFP）的变化，复发率及生存期，并纳入与预后相关的危险因素，先通过单因素条件的 Logistic 回归分析预后的相关危险因素，再采用 COX 风险模型对影响预后的相关危险因素进行分析。结果治疗后患者的 AFP 及肝功能均明显改善，与治疗前比较差异有统计学意义（P 〈0.05）；肿瘤完全消融率达87.50%；经过治疗后的肿瘤1、2、3、4年的复发率为17.9%、29.9%、45.9%、55.0%。结论射频消融术是一种有效的治疗原发性肝癌的治疗方法，原发性肝癌预后危险因素为肿瘤的分化程度、肿瘤复发、TNM 分期、AFP、术中输血、手术方式、肿瘤和手术部位、术前转氨酶水平。Objective To evaluate the radiofrequency ablation in treatment of primary and recurrent liver cancer and to explore the risk factors affecting prognosis.Methods 1 64 patients with primary and recurrent liver cancer underwent radiofrequency ablation treatment.The clinical data including liver function before and after treatment,alpha-fetoprotein （AFP）,the rate of relapse and survivalwere retrospectively analyzed.The univariate Logistic regression analysis was used to analyzed the risk factors associated with the prognosis.Then the risk prognostic factors were analyzed using COX risk model.Results After treatment,AFP and liver function were significantly improved in patients （P〈0.05）;Complete tumor ablation rate was 87.50%.After cancer treatment 1,2,3,4 years,the recurrence rate was 17.9%,29.9%, 45.9% and 55.0% respectively.Conclusion Radiofrequency ablation is an effective treatment for primary liver cancer treatment,the risk factors affecting prognosis include tumor differentiation,tumor recurrence,TNM stage,AFP,intraoperative blood transfusion, surgical,cancer and surgical site before surgery transaminase levels.

关 键 词：原发性肝癌 射频消融术 

分 类 号：R815[医药卫生—放射医学] R735.7[医药卫生—临床医学]