骨髓间充质干细胞治疗充血性心力衰竭的研究现状  

Therapeutic Progress of Congestive Heart Failure Treated with Mesenchymal Stem Cells

作　　者：刘圣辰[1] 王强[1] 卢子润[1] 王东进[1] 

机构地区：[1]南京大学医学院附属鼓楼医院心胸外科,南京210008

出　　处：《中国胸心血管外科临床杂志》2016年第11期1108-1111,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金(81370239)~~

摘　　要：充血性心力衰竭(congestive heart failure,CHF)是心肌梗死的并发症,严重影响人类的健康,尽管目前药物治疗CHF的效果已经有很大提高,但如何彻底使由心肌梗死所导致的损伤心肌复原仍然是个世界性问题。骨髓间充质干细胞(mesenchymal stem cells,MSCs)移植已被证实能够修复梗死的心肌,大量证据表明MSCs可以在人和动物体内产生新的心肌细胞。本篇综述将探讨MSCs移植治疗CHF这一问题。Congestive heart failure is a complication of myocardial infarction threatening human health. Although the pharmacotherapy is effective, it is still a worldwide challenge to thoroughly repair the in）ured myocardium induced by myocardial infarction. It has been demonstrated that mesenchymal stem cells （MSCs） can repair infarcted myocardium. Much evidence shows that MSCs can generate new myocardial ceils in both human and animals＇ hearts. This review aims at discussing the therapeutic progress of the congestive heart failure treated with MSCs.

关 键 词：充血性心力衰竭 骨髓间充质干细胞 心肌再生 细胞移植 

分 类 号：R541.61[医药卫生—心血管疾病]