哺乳动物中雌激素对铁代谢的影响（英文）  

Effect of estrogen on iron metabolism in mammals

作　　者：杨晓[1] 许曼曼[2] 王俊[2] 谢俊霞[2] YANG Xiao XU Man-Man WANG Jun XIE Jun-Xia(Class 9, Grade 2013, Medical College of Qingdao University, Qingdao 266071, China Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders and State Key Disciplines： Physiology （in incubation）, Medical College of Qingdao University, Qingdao 266071, China)

机构地区：[1]青岛大学临床医学院,青岛266071 [2]青岛大学医学院生理学教研室,山东省神经相关疾病重点实验室,山东省神经退变疾病协同创新中心,青岛266071

出　　处：《生理学报》2016年第5期637-643,共7页Acta Physiologica Sinica

基　　金：supported by grants from the National Key Basic Research Program of China (No. 2011CB504102);the National Natural Science Foundation of China (No. 31571054, 81430024);Excellent Innovative Team of Shandong Province and Taishan Scholars Construction Project, China

摘　　要：雌激素是一种类固醇激素,主要由卵巢产生,通过与受体结合来发挥其生物学效应并对机体代谢产生影响。研究者发现在动物体内雌激素水平的变化同时也伴随着机体内铁的储量的变化。近几年雌激素反应元件(estrogen response element,ERE)的发现提示雌激素能够直接参与哺乳动物铁代谢的调节。本文就雌激素参与机体各个系统铁代谢的调节及相关机制做了综述,以期为雌激素的临床用药提供指导。雌激素与铁代谢关系密切,其具体调节机制还有待进一步深入探讨。Estrogen is a steroid hormone produced mainly by the ovaries. It combines with the nuclear receptors to exert the biological effects influencing the metabolism of body. Elevated levels of estrogen are often associated with altered iron levels in mammals. Fur- thermore, the findings of estrogen response element （ERE） have demonstrated that estrogen affects iron metabolism directly in periph- eral tissues. In this review, we will briefly summarize the effect of estrogen on iron metabolism in mammals, and discuss recent prog- ress in the mechanisms of estrogen on some iron related proteins in order to provide guidance for clinical use of estrogen. Estrogen and iron metabolism are closely related, but the exact regulatory mechanisms still need further exploration.

关 键 词：雌激素 铁 雌激素反应原件 

分 类 号：Q493[生物学—生理学]