光遗传学技术在疼痛研究中的应用  

Application of optogenetic technique in pain research

作　　者：李毅[1] 郝瀚[1] 张海林[1] 杜肖娜[1] LI Yi HAO Han ZHANG Hai-Lin DU Xiao-Na(Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China)

机构地区：[1]河北医科大学药理教研室,石家庄050017

出　　处：《生理学报》2016年第5期655-660,共6页Acta Physiologica Sinica

基　　金：国家自然科学基金项目(No.31571088);河北省应用基础研究计划重点基础研究项目(No.16967712D)资助

摘　　要：疼痛是影响广泛的临床问题,目前对于疼痛还缺乏非常有效的特异性药物和治疗方法。疼痛的传导通路涉及外周、脊髓和脊髓上多个水平,具有复杂多样性的特点。要解决疼痛方面的问题,首先要对疼痛感觉通路和神经生物学机制有清晰的认识。光遗传学方法是一项能够选择性激活体内特定类型神经元的技术,该技术的发展为深入解析神经系统多种传导通路以及调控机制提供了可能。本文综述了迄今在疼痛研究领域的光遗传学技术研究进展,并列举了在疼痛研究中有潜在应用价值的新型光遗传学方法。Chronic pain represents a major clinical issue which so far is still in shortage of selective and effective treatment. Multiple components are involved in the pain processing, including peripheral, spinal and supraspinal levels of the nervous system. The core to fight the pain problem effectively is to have a good understanding of nociceptive mechanism and the neurobiology of pain perception. Optogenetic technique allows selective activation of subpopulation neurons and provides possibility for better understanding of com- plex pathway and modulation mechanism in nervous system. Here we review the researches to date that used optogenetic tools for studying pain pathway, and we also provide a brief overview of some new development in optogenetic techniques that may have great potentials in pain research.

关 键 词：疼痛 光遗传学 伤害性感受器 背根神经节 脊髓 

分 类 号：R402[医药卫生—临床医学]