血清硫酸去氢表雄酮水平与慢性荨麻疹关系的Meta分析  

Association between Dehydroepiandrosterone-sulfate and Chronic Urticaria: A Meta-analysis

作　　者：宁小丽[1] 臧运书[1] 潘敏[1] 

机构地区：[1]青岛大学附属医院皮肤科,山东青岛266003

出　　处：《中国循证医学杂志》2016年第10期1131-1136,共6页Chinese Journal of Evidence-based Medicine

摘　　要：目的综合评价血清硫酸去氢表雄酮(dehydroepiandrosterone-sulfate,DHEA-S)水平与慢性荨麻疹的关系。方法计算机检索The Cochrane Library(2015年3期)、Pub Med、EMbase、CBM、VIP、Wan Fang Data和CNKI数据库,搜集有关血清DHEA-S水平与慢性荨麻疹关系的病例-对照研究,检索时限从建库至2016年1月。由2名研究人员独立进行文献筛选、资料提取和纳入研究的偏倚风险评价,而后采用Rev Man 5.3软件进行Meta分析。结果共纳入8篇文献,包括9个研究。Meta分析结果显示:DHEA-S水平与慢性荨麻疹相关[SMD=–0.93,95%CI(–1.35,–0.50),P<0.000 01]。根据DHEA-S测量方法的不同进行亚组分析,三种测量方法均显示DHEA-S水平与慢性荨麻疹相关[电化学发光免疫分析技术:SMD=–0.75,95%CI(–1.08,–0.42),P<0.000 01;酶联免疫吸附试验:SMD=–0.59,95%CI(–0.87,–0.31),P<0.000 1;酶免疫测定法:SMD=–2.70,95%CI(–3.30,–2.10),P<0.000 01]。敏感性分析结果显示结果稳定、可靠。结论低水平的DHEA-S可能与慢性荨麻疹的发生有关。受纳入研究质量和数量的限制,上述结论需进一步开展高质量的研究予以验证。Objective To systematically review the association between dehydroepiandrosterone-sulfate（DHEA-S） and chronic urticarial（CU）. Methods We searched databases including The Cochrane Library（Issue 3, 2015）, Pub Med, EMbase, CBM, VIP, CNKI and Wan Fang Data from inception to January 2016, to collect case-control studies about the association between DHEA-S and CU. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Meta-analysis was performed by using Rev Man 5. 3 software. Results A total of 8 papers involving 9 case-control studies were included. The results of meta-analysis showed that DHEA-S might be associated with CU（SMD= – 0. 93, 95 %CI – 1. 35 to – 0. 50, P〈0. 000 01）. Subgroup analysis by the difference of measuring methods, indicated that DHEA-S might be associated with CU（ECLIA： SMD= – 0. 75, 95 %CI – 1. 08 to – 0. 42, P〈0. 000 01; ELISA： SMD= – 0. 59, 95 %CI – 0. 87 to – 0. 31, P〈0. 000 1; EIA： SMD= – 2. 70, 95 %CI – 3. 30 to – 2. 10, P〈0. 000 01）. Sensitivity analysis showed that our results were reliable and stable. Conclusion The meta-analysis suggests that DHEA-S might be associated with CU. Due to the limited quality and quantity of included studies, more high quality studies are needed to verify the above conclusion.

关 键 词：慢性荨麻疹 硫酸去氢表雄酮 病例-对照研究 META分析 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]