新型除草剂丙嗪嘧磺隆的合成研究  

Study on the Synthetic Process of Novel Herbicide Propyrisulfuron

作　　者：刘安昌[1] 张树康 余彩虹[1] 余玉[1] 董元海 

机构地区：[1]武汉工程大学化工与制药学院,武汉430074

出　　处：《世界农药》2016年第5期30-32,共3页World Pesticide

摘　　要：以6-氯-3-氨基哒嗪和溴乙酸为起始原料,在三乙胺的作用下反应得到-亚氨基-6-氯-2,3-二氢哒嗪-2-乙酸,然后在三氯氧磷的催化下环化,再经正丙基溴化镁格氏反应得到2-氯-6-正丙基咪唑并[1,2b]吡嗪;2-氯-6-正丙基咪唑并[1,2b]吡嗪经磺酰氯磺酰化和胺化,最后与4,6-二甲氧基-2-嘧啶胺碳酸苯酯反应得到目的化合物丙嗪嘧磺隆。总收率35.0%。经核磁共振分析,所得化合物与目的产物丙嗪嘧磺隆结构一致。3-Amino-6-chloro-2,3-dihydro pyridazine-2-acetic acid was obtained from the reaction of 3-amino-6-chloro-pyridazine and bromide acetic acid with the catalyzer of triethylamine, and then it experienced a sulfonation reaction catalysed by phosphorus oxychloride. And n-propylmagnesium bromide Grignard reaction generating 2-chloro-6-n-propyl imidazole [1,2b]pyrazine. 2-Chloro-6-n-propyl imidazole [1,2b]pyrazine sulfonylation and amination took place, and the compound obtained and reacted with phenyl n-（4,6-dimethoxypyrimidin-2-yl）carbamate to give the target compound. The total yield was 35.0%. Analysis of nuclear magnetic resonance （1HNMR） showed the compound obtained had the same structure as propyrisulfuron with the same structure.

关 键 词：丙嗪嘧磺隆 除草剂 合成 

分 类 号：TQ457.2[化学工程—农药化工]