实时弹性成像技术在脑死亡供肝及肝移植术后早期效果评估的临床价值初探  

A preliminary study of real-time elastic imaging technique in evaluating the liver of brain death donor and the livers of patients after liver transplantation

作　　者：牛宁宁[1] 唐缨[1] 郭庆军[1] 赵静雯[1] 刘洋[1] 张国英[1] 

机构地区：[1]天津市第一中心医院,300192

出　　处：《中华超声影像学杂志》2016年第10期875-878,共4页Chinese Journal of Ultrasonography

基　　金：天津市卫生局科技基金（13KGl02）;天津市科委项目（15JCYBJC27000）

摘　　要：目的应用实时组织弹性成像（RTE）技术对脑死亡供肝及肝移植术后受体肝脏的硬度进行评价，探讨其在脑死亡供肝评估中的应用价值。方法脑死亡供肝24例术前分别行电镜和超声弹性成像检测，肝移植术后第1d、第7d行超声弹性成像检测。根据电镜结果分为肝纤维化组（12例）和非纤维化组（12例），并对结果进行对比分析。（MEAN）小于非纤维化组，两组差异有统计学意义结果在脑死亡供肝中，纤维化组的应变均值（P〈0．05）；在肝移植术后第1d受体肝纤维化组的MEAN值小于非纤维化组，两组差异有统计学意义（P〈0．05）；在肝移植术后第7d受体肝纤维化组的MEAN值与非纤维化组差别不大，两组差异无统计学意义（P〉0．05）。结论弹性成像可以评价脑死亡供肝的肝脏硬度，并可以动态监测肝移植术后肝脏硬度的改变，有望成为供肝评估的新方法。Objective To evaluate the liver stiffness of brain death donor and patients after liver transplantation by real-time elastic imaging （RTE）, to explore the application value of RTE in evaluating the brain death donor. Methods Twenty-four cases of brain death donor were detected by electron microscope and RTE, after liver transplantation, the liver of receptors were detected at the first day and the seventh day. According to electron microscopy results, 24 cases were divided into 2 groups： the liver fibrosis group （12 cases） and the non fibrosis group （12 cases）,and the results were compared and analyzed. Results In the liver of brain death donor and at the first day after liver transplantation, the MEAN value of the fibrosis group was greater than that of the non fibrosis group, and there were significant differences between them （P〈0.05）;At the seventh day after liver transplantation, there was little difference in the MEAN value between the fibrosis and the non fibrosis group（ P 〈0.05）. Conclusions Elastic imaging can evaluate the liver stiffness of brain dead donor liver, and can dynamically monitor the changes of liver stiffness after liver transplantation, and it is expected to be a new method for liver evaluation.

关 键 词：弹性成像技术 肝移植 脑死亡 供体 

分 类 号：R657.3[医药卫生—外科学] R445.1[医药卫生—临床医学]