新生儿血培养病原菌分布及耐药性分析  

Analysis of the Pathogens Isolated from Blood Specimens of Neonates and Their Antibiotic Resistance

作　　者：刘雪梅[1] 迟富丽[1] 谈华[1] 朱纯亮[1] 韩勍[1] 徐飞[1] 

机构地区：[1]南京医科大学附属儿童医院检验科,江苏南京210008

出　　处：《南京师大学报（自然科学版）》2016年第3期106-109,共4页Journal of Nanjing Normal University(Natural Science Edition)

摘　　要：为了解本院新生儿病房血培养病原菌的分布及主要病原菌对抗菌药物的耐药性,本研究分析了2015年1月至2015年12月新生儿病房送检的血培养标本所分离病原菌的种类及抗菌药物耐药情况.结果共分离到病原菌236株,其中革兰阳性菌192株(81.36%),以凝固酶阴性葡萄球菌为主;革兰阴性杆菌40株(16.95%),以大肠埃希菌为主.药敏结果显示,凝固酶阴性葡萄球菌耐药率较高,其中耐甲氧西林检出率占82.69%,未检出耐奎奴普丁/达福普汀、替加环素、利奈唑烷和万古霉素的葡萄球菌;主要革兰阴性菌对氨苄西林、复方新诺明、庆大霉素耐药率较高,未检出耐阿米卡星、头孢吡肟、头孢他啶、头孢替坦、妥布霉素、亚胺培南菌株.结论:本院新生儿血培养病原菌以革兰阳性菌为主,凝固酶阴性葡萄球菌是主要病原菌,并且耐药率较高.To investigate the distribution and antibiotic resistance of pathogens isolated from blood specimens of neonates, the clinical data of neonatal blood cultures were statistically analyzed from January 2015 to December 2015. A total of 236 pathogenic strains were isolated, including gram-positive bacteria （81.36%）, Coagulase-negative Staphylococcus were predominant ; 40 strains of gram-negative bacteria Eseheriehia eoli were predominant. The drug resistances of Coagulase-negative Staphylococcus were high, MRCNS were 82.69%, no Quinupristin/Dalfopristin, Tigecyeline, Vaneomyein and Linezolid resistant strains were found. The resistances of main Gram-negative pathogens to Ampicillin, SMZ-TMP, Levofloxaein, Gentamicin were high. No Amikacin, eefepime, ceftazidime, cefotetan, tobra- mycin, imipenem resistant strains were found. The refuhs showed that Gram-positive bacteria were the main pathogens in the hosptial, among which Coagulase-negative Staphylococcus was the predominant pathogen with high drug resistance.

关 键 词：血培养 新生儿 病原菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]