封闭群子午沙鼠的寄生虫感染及药物净化效果  

Parasitic infection in a closed group of outbred Meriones meridianus and results of parasite eradication

作　　者：徐艺玫 王新国[2] 史深 罗芸 张燕 燕顺生 戴小华[3] 赵红琼[3] 

机构地区：[1]新疆实验动物研究中心,乌鲁木齐830002 [2]新疆疾病预防控制中心,乌鲁木齐830002 [3]新疆农业大学,乌鲁木齐830002

出　　处：《中国实验动物学报》2016年第5期499-502,共4页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然基金项目(编号:31460579)

摘　　要：目的为建立清洁级子午沙鼠种群奠定基础,为制定子午沙鼠寄生虫检测标准提供参考依据。方法对封闭群子午沙鼠寄生虫感染情况进行调查研究,选择胺菊·氯菊酯、吡喹酮、替硝唑三种药物,分为高、中、低剂量对子午沙鼠用药,观察子午沙鼠体内外寄生虫驱除情况。结果在子午沙鼠体内检出鼠三毛滴虫和短膜壳绦虫两种体内寄生虫,体外寄生虫有鼠肉螨。高、中、低剂量组能不同程度杀死子午沙鼠体表食肉螨,鼠肉螨用1%的胺菊·氯菊酯药浴子午沙鼠三次即可驱除子午沙鼠体表的鼠肉螨,有螨动物只数为零。吡喹酮中剂量组(31 mg/kg)有完全杀死子午沙鼠体内短膜壳绦虫的作用,且为最佳给药剂量。替硝唑中剂量组(42 mg/kg)为净化子午沙鼠体内鼠三毛滴虫的最佳剂量。结论现有的子午沙鼠体内有鼠三毛滴虫和短膜壳绦虫感染,体外有鼠肉螨寄生,三种抗寄生虫药物具有选择性驱除这些寄生虫的作用。Objective In order to lay the foundation for establishment of a clean grade Meriones meridianus population,and provide reference for the formulation of Meriones meridianus parasite detection standard. Methods A survey of parasite infection in Meriones meridianus was carried out,and three kinds of antiparasitic drugs,tetramethrin/permethrin,praziquantel,and tinidazole were used in high-,medium-and low-doses for eradication of the target parasites.Results Three types of parasites were detected among the animals. The infection rate of surface parasite Myobia musculi was 82. 1%（ 23 /28）,that of intestinal parasite Hymenolepis nana was 78. 1%（ 25 /32） and Tritrichomonas muris was90. 6%（ 29 /32）. Significant results of parasite eradication were achieved with the antiparasitic drugs. Medicated bath using 1% tetramethrin/permethrin for 30 s every 4 days for 5 times and 1. 5% tetramethrin/permethrin for 30 s every 4 days for 3 times completely eradicated the surface Myobia musculi infection. Praziquantel in a dose of 31 mg/kg by daily gastric gavage for consecutive 7 days was the optimal dosage to completely eradicate the intestinal Hymenolepis nana. Tinidazole in a dose of 42 mg/kg administered by gastric gavage daily for consecutive 7 days was the optimal dosage for eradication of intestinal Tritrichomonas muris infection. Conclusions Three types of parasites are detected in Meriones meridianus in our laboratory,i. e. surface infection with Myobia musculi,and intestinal infection with Tritrichomonas muris and Hymenolepis nana. Tetramethrin/permethrin,praziquantel and tinidazole can be used to effectively eradicate these three types of para-sites,respectively.

关 键 词：子午沙鼠 寄生虫检测 药物净化 鼠三毛滴虫 短膜壳绦虫 鼠肉螨 

分 类 号：Q95-33[生物学—动物学]