鹿复合麻醉剂对鹿血浆一氧化氮、内皮素及降钙素基因相关肽及血流动力学影响  

Effect of the Combined Anesthetic for Deer on NO,Endothelin,Calcitonin Gene Related Peptide and Hemodynamics in Deer

作　　者：尹柏双[1] 李雨航[1] 王楠[1] 王雪莹[1] 宋永利[1] 付连军[1] 

机构地区：[1]吉林农业科技学院动物科技学院,吉林吉林132101

出　　处：《中国兽医杂志》2016年第9期22-24,共3页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金项目(31302150);吉林省科技厅发展计划项目(20140204062NY);吉林省教育厅"十二五"科学技术项目(吉教科合字2014379);吉林农业科技学院博士启动基金项目(吉农院合字2012307);吉林农业科技学院种子基金项目(吉农院合字2013905)

摘　　要：为研究鹿复合麻醉剂作用下血浆中一氧化氮(NO)、内皮素(ET)和降钙素基因相关肽(CGRP)含量变化与血流动力学变化的相关性,探讨鹿复合麻醉剂引起鹿血流动力学变化的部分机理。试验选取6只健康成年梅花鹿,肌肉注射鹿复合麻醉剂0.04 m L/kg体重,注药前及注药后15、30、45、60、75、90、120 min进行收缩压、舒张压、平均动脉压及心率的监测,并同步采集颈静脉血样测定NO、ET和CGRP含量。结果表明,麻醉期鹿血浆ET变化与收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)和心率(HR)变化趋势大致相似,存在着一定相关性(P<0.01);CGRP变化与上述指标变化趋势相反,存在一定负相关性(P<0.01);NO变化不显著(P>0.05)。结果提示,鹿复合麻醉剂作用下引起ET和CGRP含量的变化参与了鹿血流动力学的调节。In order to investigate the combined anesthetic for deer（CAD）on the relationship of nitric oxide（NO）,Endothelin（ET）and calcitonin gene related peptide（CGRP）in plasma and the changing of hemodynamics in deer,6 healthy grown deer were injected with the drug（0.04 m L/kg）,and the Jugular vein blood was collected at 0,15,30,45,60,75,90,120 min before and after administration.At the same time,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,mean arterial pressure（MAP）and heart rhythm（HR）were monitored. NO,ET and CGRP in plasma were determined by Elisa. Results showed that ET was changed similar to that of hemodynamics,and the correlation between them was found.A negative correlation was observed between the CGRP and hemodynamics.It is concluded that ET and CGRP participate in changing of hemodynamics caused by the CAD.

关 键 词：鹿复合麻醉剂 血流动力学 内皮素 一氧化氮 降钙素基因相关肽 

分 类 号：S859.791[农业科学—临床兽医学]