桃核承气汤对大鼠肝性脑病模型干预治疗的分析  

Analysis of the preventive and therapeutic effects of Taohe Chengqi decoction on a rat model of hepatic encephalopathy

作　　者：李晓娟[1] 朱云[2] 王立福[2] 杜宁[2] 孙永强[2] 宋雪艾[2] 景婧[2] 王丽苹[2] 张帆[2] 余思邈[2] 王睿林[2] 李瑞生[1] LI Xiao-juan ZHU Yun WANG Li-fu DU Ning SUN Yong-qiang SONG Xue-ai JING Jing WANG Li-ping ZHANG Fan YU Si-miao WANG Rui-lin LI Rui-shengl(Research Center for Clinical and Translational Medicine Liver Disease Center for Combined TCM and Western Medicine,302 Hospital of PLA, Beijing 100039, China)

机构地区：[1]解放军第302医院临床研究管理中心,北京100039 [2]解放军第302医院中西医结合诊疗与研究中心,北京100039

出　　处：《中国比较医学杂志》2016年第10期14-18,共5页Chinese Journal of Comparative Medicine

基　　金：国家"十二五"科技重大专项资助项目(2012zx10005010-002-002)

摘　　要：目的探讨桃核承气汤(去甘草)对硫代乙酰胺(TAA)诱导的大鼠肝性脑病的干预治疗作用。方法通过TAA腹腔注射诱导建立大鼠肝性脑病模型,观察桃核承气汤(去甘草)颗粒对肝性脑病的神经行为改变、神经病学测试、血清生化指标及肝脏和脑病理损伤的影响。结果本实验成功构建了大鼠肝性脑病模型。桃核承气汤(去甘草)颗粒低、中、高剂量均能不同程度地改善TAA引起的HE大鼠的神经反射情况,降低HE级别,降低血氨和生化指标指数以及使病理结果均呈现减轻的现象,其中以高剂量组为最佳(P<0.05),效果与阳性药相近。结论桃核承气汤(去甘草)对TAA引起的大鼠肝性脑病有较好的预防治疗作用,本实验为该方剂的临床肝性脑病的使用提供了坚实的实验依据。Objective To analyze the preventive and therapeutic effects of a traditional Chinese medicine Taohe Chengqi decoction on a rat models of hepatic encephalopathy（ HE） induced by thioacetamide（ TAA）. Methods The rat model of HE was established by intraperitoneal injection of TAA,and the effects of Taohe Chengqi decoction were observed by neurobehavioral changes,neurological test,blood ammonia,serum biochemical indexes,and liver and brain pathological examination. Results The rat model of hepatic encephalopathy was successfully established. Low,medium and high dose Taohe Chengqi decoction markedly improved neuro-reflexes and liver and brain pathological damages,and significantly decreased the HE staging and serum biochemical indexes,and the results of high dose group was the best,similar to that of positive drug-treatment group. Conclusions Taohe Chengqi decoction exhibits promising preventive and therapeutic effects on the rat model of TAA-induced hepatic encephalopathy,and these results provide substantial experimetal evidence for its clinical application.

关 键 词：桃核承气汤 肝性脑病 硫代乙酰胺 大鼠 

分 类 号：R33[医药卫生—人体生理学]