^(131)I和甲巯咪唑对Graves病患者外周血Treg细胞及IL-10水平的影响  

Effect of ^(131)I and Methimazole on Treg Cells and IL-10 in Graves Disease

作　　者：胡希红[1] 魏广玉[1] 倪红 

机构地区：[1]大连市友谊医院老年病科,116001 [2]大连市老年病医院老年病科,116011

出　　处：《医学研究杂志》2016年第10期114-116,127,共4页Journal of Medical Research

摘　　要：目的观察^(131)I和甲巯咪唑治疗Graves病(GD)前后调节性T细胞(Treg)和白细胞介素-10(IL-10)的变化,并探讨其相关的临床意义。方法选取2013年4月~2015年11月笔者医院收治的GD患者88例,随机分为^(131)I治疗组和甲巯咪唑治疗组,每组44例。选择同期笔者医院健康体检者40例作为正常对照。血清IL-10的检测使用ELISA法,流式细胞仪检测Treg细胞。比较两组治疗前后FT_3、FT_4和TSH。结果 GD患者Treg细胞比例为3.25%±0.84%,显著低于正常对照组的7.14%±2.13%(P<0.01),GD患者IL-10因子表达为8.22±1.73μmol/L,也显著低于正常对照组的15.64±3.17μmol/L(P<0.01)。^(131)I和甲巯咪唑组治疗前GD患者Treg细胞比例和IL-10因子表达差异无统计学意义(P>0.05),治疗后^(131)I组Treg细胞比例和IL-10因子表达出现显著升高(P<0.05),但甲巯咪唑组上述指标治疗前后无显著性差异(P>0.05)。^(131)I和甲巯咪唑组治疗前GD患者FT_3、FT_4和TSH差异无统计学意义(P>0.05),治疗后两组FT_3和FT_4均显著减低(P<0.01),TSH均显著升高(P<0.05)。但^(131)I组对FT_3和FT_4的减低作用以及对TSH的升高作用显著优于甲巯咪唑组(P<0.05)。结论 ^(131)I可提高Graves病患者Freg细胞比例和IL-10因子表达,临床疗效显著。Objective To detect the effect of ^131I and methimazole on Treg cells and IL - 10 in Graves disease（GD） and explore its related clinical significance. Methods A total of 88 GD patients were enrolled in this study. Patients were randomly divided into： ^131I group （n = 44） and methimazole group（ n = 44）. Another 40 health person serred as normal control. Serum IL - 10 was detected by E LISA method. Flow cytometry was used to detect Treg cells. FT3 , FT4 and TSH was compared between the two groups before and after treatment. Results The proportion of Treg ceils in GD patients was 3.25% ±0. 84% , which was significantly lower than that of 7. 14% - 2.13 % in normal control group （P 〈 0.01 ） and IL - 10 expression in GD patients was 8.22 ± 1.73μmol/L, which was significantly lower than that of 15.64 ± 3.17μmol/L in normal control group （P 〈 0.01 ）. After treatment, Treg cells and IL - 10 expression were significantly increased in ^131I group （P 〈 0.05） , but which was not changed in methimazole group （P 〉 0.05）. After treatment, the effect of reducing FT3 , FT4 and increasing of TSH in ^131I group was significantly higher than that of methimazole group （P 〈 0.05）. Conclusion 1311 can increase Treg cells and IL- 10 expression in GD patients, with significantly clinical effect.

关 键 词：GRAVES病 ^131I 甲巯咪唑 调节性T细胞(Treg) 白介素-10 

分 类 号：R581.1[医药卫生—内分泌]