阿托伐他汀治疗终末期肾脏病患者颈动脉粥样硬化前后的超声表现差异性研究  

Study on Ultrasound of Carotid Atherosclerosis in Patients with End Stage Renal Disease before and after Treatment by Atorvastatin

作　　者：莫祝宁[1] 孔晓玲[1] 韦兴来[1] 符安[1] 陈海燕[1] 刘江泽[1] 梁洁梅[1] 覃君菊 

机构地区：[1]玉林市第一人民医院超声科,537000

出　　处：《医学研究杂志》2016年第10期124-127,共4页Journal of Medical Research

基　　金：玉林市科学研究与技术开发计划项目(玉科技2014703 Φ3)

摘　　要：目的研究阿托伐他汀治疗终末期肾脏病患者颈动脉粥样硬化前后的超声表现差异性。方法选取2013年3月～2015年1月在笔者医院进行治疗的终末期肾脏病患者80例作为研究对象，使用彩色多普勒超声诊断仪观察患者使用阿托伐他汀治疗前后颈动脉中膜厚度（IMT）、管腔内径（AD），平均斑块个数、不稳定斑块数、斑块积分，并根据收缩期峰值血流速度（PSV）、舒张期末血流速度（EDV）计算阻力指数（RI）。结果治疗前患者IMT、AD、平均斑块个数、不稳定斑块数、斑块积分、PSV、EDV、R1分别为1．48±0．37mm、7．55±0．91mm、3．51±1．02、64．31±5．42、3．12±0．74、47．36±16．05cm／s、14．13±6．31cm／s、0．76±0．20，治疗后分别为0．88±0．26mm、8．62±1．34mm、2．27±0．94、41．54±3．87、1．97±0．50、48．42±11．82cm／s、15．42±8．32cm／s、0．71±0．17，患者治疗后IMT、平均斑块个数、不稳定斑块数、斑块总积分与治疗前相比均有明显下降，AD比治疗前明显增宽，差异均有统计学意义（P〈0．05），治疗后PSV、EDV与治疗前相比略有升高，RI有所降低，但差异均无统计学意义（P〉0．05）。结论阿托伐他汀对于颈动脉粥样硬化有明显的缓解作用，超声诊断能准确检测终末期肾脏病患者颈动脉粥样硬化情况，为患者治疗和预后提供可靠帮助。Objective To study the differences of ultrasound of carotid atherosclerosis in patients with end stage renal disease before and after treatment by atorvastatin. Methods Eighty cases of patients with end stage renal disease in our hospital from March 2013 to January 2015 were selected as the research subjects, who were detected the carotid artery intima -media thickness （IMT） , lumen diameter （AD） , mean patch number, unstable patch number, patch integral by Doppler ultrasound diagnostic apparatus,then the resistance index （RI） was calculated according to the peak systolic velocity （PSV） , diastolic ending flow velocity （EDV） before and after using atorvastatin statin therapy. Results The IMT,AD,mean patch number, unstable patch number, patch integral,PSV, EDV and RI of the patients before treatment were respectively 1.48 ± 0.37mm, 7.55 ± 0.91mm, 3.51 ± 1.02,64.31 ± 5.42,3. 12 ± 0.74,47.36 ± 16.05cm/s, 14. 13 ± 6.31cm/s and 0.76 ±0.20, which were respectively 0.88 ± 0.26mm, 8.62 ± 1.34mm, 2.27 ± 0.94, 41.54 ± 3.87,1.97 ± 0.50,48.42 ± 11.82cm/s, 15.42 ± 8.32em/s and 0.71 ± 0. 17 after treatment,among which the IMT,mean patch number, unstable patch number,patch integral of patients significantly decreased compared with those before treatment,and the AD was wider than that before treatment, between which the differences were statistically significant （P 〈 0.05 ）. The PSV and EDV after treatment slightly increased compared with those before treatment, and RI slightly decreased, between which there was no significant difference （ P 〉 0. 05 ）. Conclusion Atorvastatin has a significant effect on carotid atherosclerosis,and ultrasound examination can accurately detect carotid atherosclcrosis in patients with end stage renal disease, provide reliable help for the treatment and prognosis of patients.

关 键 词：超声诊断 阿托伐他汀 终末期肾病 动脉粥样硬化 阻力指数 

分 类 号：R9[医药卫生—药学]