血液胆碱酯酶活性作为生物监测指标应用中的注意事项  

Concerns on Applying Blood Cholinesterase Activity as Bio-Monitoring Indicator

作　　者：李建 黄发明 

机构地区：[1]江苏蓝天安全科技有限公司,江苏南通226004

出　　处：《环境与职业医学》2016年第10期1008-1011,共4页Journal of Environmental and Occupational Medicine

摘　　要：在有机磷农药急性暴露和慢性接触的不同方式下,血液胆碱酯酶活性变化呈现不同的规律特征。本文介绍了血液胆碱酯酶活性监测作为替代性生物效应标志,来反映有机磷农药急性暴露对机体胆碱能神经组织毒性作用的意义及其职业病临床应用价值;分析了血液胆碱酯酶活性测定值受暴露时点时程、监测时段、病程时相、酶活性再生阶段等多种时间相关因素的影响;介绍了长期低剂量接触有机磷农药出现胆碱能神经毒性耐受现象时,血液胆碱酯酶活性特征及其衍生出的相关问题,以及在职业健康监护实践应用中的注意事项。The change pattern of blood cholinesterase activity among organophosphorns pesticides workers varies with acute or chronic exposure manner. In this paper, the significance of blood cholinesterase activity assay, serving as a surrogate effect biomarker to reflect the neurotoxicity in target cholinergie nerve tissues due to acute exposure to organophosphorus pesticides, and its application values in occupational medicine clinical practice were introduced; and multiple time-related influencing factors relevant to this assay such as duration and time point of exposure, monitoring time period, stage of disease course, and phase of enzyme activity regeneration process were also analyzed. Meanwhile, the characteristics of enzyme activity and derived issues in occurrence of cholinergic neurotoxicity tolerance after long-term low-level exposure to organophosphorus pesticides and the considerations of this assay for occupational health surveillance were described.

关 键 词：血液胆碱酯酶活性 生物监测 有机磷农药 职业卫生与职业健康评价 

分 类 号：R135.1[医药卫生—劳动卫生]