不同的胚胎移植管对体外受精-胚胎移植技术结局的影响  

Effect of catheter choice during embryo transfer on the clinical outcome of in vitro fertilization-embryo transfer

作　　者：任秀莲[1] 刘平[1] 廉颖[1] 黄锦[1] 郑晓英[1] 朱亚菊[1] 乔杰[1] 

机构地区：[1]北京大学第三医院生殖医学中心,北京100191

出　　处：《北京大学学报（医学版）》2016年第5期905-909,共5页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金(81501325)资助~~

摘　　要：目的：比较不同的胚胎移植管对新鲜体外受精-胚胎移植技术（in vitro fertilization-embryo transfer,IVF-ET）妊娠结局的影响。方法：自2012年7月至2013年11月,由同一移植医生完成前瞻性对照研究,选取在北京大学第三医院生殖医学中心完成IVF-ET/卵胞浆内单精子注射（intracytoplasmic sperm injection,ICSI）-ET治疗的2 064个新鲜胚胎移植周期,分为两组,组1采用Cook Sydney IVF移植管（型号：K-JETS-7019-SIVF）移植,共949周期,组2采用Frydman~CCD管（型号：131230301）移植,共1 115周期,比较不同的移植管对IVF结局的影响。结果：在年龄、不孕原因、促排卵方案、平均获卵数、平均移植胚胎数及胚胎评价等基本情况一致的情况下,组1的着床率、临床妊娠率及活产率均显著高于组2（34.40%vs.26.92%,51.21%vs.41.52%,42.57%vs.33.09%,P值均〈0.05）,两组流产率差异没有统计学意义（11.93%vs.15.98%,P〉0.05）,组1的困难移植比例高于组2（5.27%vs.3.41%,P〈0.05）,两组困难移植周期的临床妊娠率及活产率无显著差异。结论：不同移植管可能会影响IVF结局,COOK Sydney IVF移植管可获得较好的临床妊娠结果。Objective： To compare two flexible embryo catheters and determine whether clinical outcome differs in the in vitro fertilization-embryo transfer（ IVF-ET） cycles. Methods： This prospective control study was conducted by one doctor between July 2012 and November 2013. In the study,2 064 patients undergoing fresh embryo transfer by using IVF-ET / intracytoplasmic sperm injection（ ICSI）-ET in Reproductive Medical Center of Peking University Third Hospital were recruited. The subjects were divided into two groups. Cook Sydney IVF embryo transfer catheters（ product model： K-JETS-7019-SIVF）were used for embryo transfer in group 1（ n = 949）,and Frydman~ CCD catheters（ product model：131230301） were used in group 2（ n = 1 115）. Pregnancy outcomes were compared between these two groups. Results： There was no significant difference in age,diagnosis for infertility and stimulation protocol used between the two groups. In addition,there was no difference in the number of oocytes collected and in the number and score of embryos transferred. The significantly higher implantation rate,clinical pregnancy rate,and live birth rate（ 34. 40% vs. 26. 92%,51. 21% vs. 41. 52%,42. 57% vs.33. 09%,P〈0. 05） were observed in group 1 compared with group 2. The abortion rate was not significantly different between the two groups（ 11. 93% vs. 15. 98%,P〈0. 05）. The proportion of difficult transfer was higher in group 1 than that in group 2（ 5. 27% vs. 3. 41%,P〈0. 05）. There was no difference in the clinical pregnancy rate and live birth rate between the two difficult transfer cycles. Conclusion： The type of embryo transfer catheter affects the clinical outcome in IVF. Good clinical outcome can be obtained by using Cook Sydney IVF catheter,which is worthy of clinical promotion.

关 键 词：受精 体外 胚胎移植 导管插入术 妊娠率 活产 

分 类 号：R711.6[医药卫生—妇产科学]