维汉两民族异常黑胆质型冠心病患者部分血栓前状态指标改变的比较  

Differences of pethromboetic state indicators between Han Chinese and Uighur abnormal savda type coronary heart disease patients

作　　者：托兰古丽·买买提库尔班 沙吉旦·阿布都热衣木 帕它木·莫合买提[2] 帕丽达·阿布来提[1] 

机构地区：[1] 新疆医科大学公共卫生学院劳动卫生与环境卫生学教研室,新疆维吾尔自治区乌鲁木齐市830011 [2] 新疆医科大学第一附属医院干部病房二科

出　　处：《中国心血管病研究》2016年第7期596-599,共4页Chinese Journal of Cardiovascular Research

基　　金：新疆少数民族科技人才特殊培养计划科研项目（项目编号：201323129）

摘　　要：目的 探讨维汉两民族异常黑胆质型冠心病患者部分血栓前状态指标间的差异。方法 选择年龄在40-75岁间，无亲缘关系的81例异常黑胆质型冠心病患者（男性62例、女性19例，平均年龄58岁）、93例非异常黑胆质型冠心病患者（男性74例、女性19例，平均年龄57岁）、132例健康人（男性82例、女性50，平均51岁），采用流式细胞仪检测法、全自动细胞仪检测法、用全自动血凝分析仪，全自动生化自动仪检测外周血中白细胞计数、血小板计数、D二聚体、凝血酶原时间、部分凝血酶时间、纤维蛋白原，并对结果进行分析。结果 维吾尔族冠心病患者中异常黑胆质证占46.39％,非异常黑胆质证占53.61％，与正常对照组相比，异常黑胆质证组和非异常黑胆质（异常血液质、异常黏液质、异常胆液质）证组D-二聚体、PT、APTT、FIB等指标间存在统计学差异（P〈0．05）,与异常黑胆质证组与非异常黑胆质证组相比D-二聚体有统计学差异（P〈0．05）。汉族冠心病患者中异常黑胆质证占46.75％,非异常黑胆质证占53.25％，与正常对照组相比，异常黑胆质证组和非异常黑胆质（异常血液质、异常黏液质、异常胆液质）证组PLT、D-二聚体、APTT、FIB等指标间存在统计学差异（P〈0．05）;与异常黑胆质证组与非异常黑胆质证组相比D-二聚体、FIB有统计学差异（P〈0．05）。维汉两民族异常黑胆质型冠心病患者血栓前状态指标间无统计学差异。结论 异常黑胆质证可能是冠心病的维医重要证型，而血栓前状态是冠心病和维吾尔医学异常黑胆质证发病的共同分子机制之一；维吾尔族和汉族异常异常黑胆质型冠心病患者分别均存在明显的血栓前状态，但维汉两民族异常黑胆质型冠心病患者血栓前状态指标间无统计学差异，可推测异常黑胆质型冠心病患者的血栓前状态指标无明显的�Objective To discuss the differences of pethromboetic state indicators between Han Chinese and Uighur coronary heart disease Patients of abnormal Savda Methods 81 cases of Abnormal Savda type coronary heart disease patients （females： 19 cases, males： 62 cases mean age： 58 years old）, 93 cases of non-abnormal Savda patients（males 74 cases, females 19 cases mean age 57 years old） and 132 healthy individuals（ males 82 cases females： 50 cases, mean age： 51 years old） were selected. Then peripheral white blood cell count, platelet count, D-dimer, partial thrombin time, thrombin time, fibrinogen were measured and the results were analyzed by using flow cytometry, full automatic cell analyzer, automatic blood coagulation analyzer, automatic biochemical analyzer.Result Among Uighur coronary artery disease patients, Abnormal Savda type occupies 46.39%, non-abnormal Savda type occupies 53.61%.Among Chinese coronary artery disease patients, Abnormal Savda type occupies 46.75%, non-abnormal Savda type occupies 53.25% . Compared to normal control group, Abnormal savda and non-abnormal Savda group D-dimer, PT, APTT and fibrinogen levels are statistically different （P〈0.05）. D-dimer and FIB level is significantly higher in Abnormal Savda group compared to non-abnormal Savda group（P〈0.05）. There is no difference in above markers between Uighur and Chinese patients. Conclusion Abnormal Savda might be an important type of Coronary heart disease in Uighur Medicine. Prethromboitic state could be one of the common change in pathological mechanism in abnormal Savda in Uighur medicine and coronary heart disease in Western medicine. There is no difference in development of abnormal Savda between different ethnic group.

关 键 词：异常黑胆质型冠心病 血栓前状态 维吾尔族 汉族 

分 类 号：R541.4[医药卫生—心血管疾病]