早产儿脑损伤、母亲绒毛膜羊膜炎及脐动脉血白细胞介素-6水平的关系  

Relationship among brain injury of preterm infant,maternal chorioamnionitis and interleukin-6 level in umbilical artery blood

作　　者：李明超[1] 邢珊[1] 

机构地区：[1]郑州市儿童医院早产儿病房,河南郑州450000

出　　处：《新乡医学院学报》2016年第10期875-877,共3页Journal of Xinxiang Medical University

摘　　要：目的分析早产儿脑损伤、母亲绒毛膜羊膜炎及脐动脉血白细胞介素-6(IL-6)水平之间的关系。方法选取2014年6月至2015年2月在郑州市儿童医院分娩的早产儿32例,应用头颅CT或超声检查早产儿脑损伤发生情况;对产妇的胎膜组织进行病理组织学检查,记录绒毛膜羊膜炎发生情况;采用酶联免疫吸附试验测定早产儿脐动脉血IL-6水平;并分析早产儿脑损伤、母亲绒毛膜羊膜炎及脐动脉血IL-6水平之间的关系。结果 32例早产儿中,母亲患有绒毛膜羊膜炎者13例(绒毛膜羊膜炎组),无绒毛膜羊膜炎者19例(无绒毛膜羊膜炎组),绒毛膜羊膜炎发生率为40.6%(13/32)。32例早产儿中,出现脑损伤者16例(脑损伤组),无脑损伤者16例(无脑损伤组),早产儿脑损伤发生率为50.0%(16/32)。绒毛膜羊膜炎组和无绒毛膜羊膜炎组早产儿脑损伤发生率分别为76.9%(10/13)和31.6%(6/19),绒毛膜羊膜炎组早产儿脑损伤发生率显著高于无绒毛膜羊膜炎组(χ2=9.743,P<0.05)。绒毛膜羊膜炎组和无绒毛膜羊膜炎组脐动脉血IL-6水平分别为(3.76±2.58)和(0.81±0.69)μg·L^(-1),绒毛膜羊膜炎组脐动脉血IL-6水平显著高于无绒毛膜羊膜炎组(t=11.517,P<0.05)。脑损伤组和无脑损伤组脐动脉血IL-6水平分别为(2.97±1.87)和(0.92±0.73)μg·L^(-1),脑损伤组脐动脉血IL-6水平显著高于无脑损伤组(t=8.975,P<0.05)。以脐动脉血IL-6≥1.2μg·L^(-1)为标准,其诊断母亲绒毛膜羊膜炎并发早产儿脑损伤的敏感度为86.77%,特异度为71.39%。结论母亲绒毛膜羊膜炎可能诱发早产儿脑损伤,脐动脉血IL-6水平可预测母体绒毛膜羊膜炎及早产儿脑损伤的发生情况。Objective To analyze the relationship among brain injury of preterm infant,maternal chorioamnionitis and interleukin-6（ IL-6） level in umbilical artery blood. Methods Thirty-two premature infants were selected in Children＇s Hospital of Zhengzhou City from June 2014 to February 2015. The brain injury of premature infants was examined by brain CT or ultrasonography. The fetal membrane tissues of puerpera were performed with histopathologic examination,and the occurrence of chorioamnionitis was recorded. The level of IL-6 in umbilical artery blood was detected by enzyme linked immunosorbent assay. The relationship among brain injury of preterm infant,maternal chorioamnionitis and IL-6 level in umbilical artery blood was analyzed. Results Among the 32 cases of premature infants,the mothers of 13 cases of premature infants had chorioamnionitis（ chorioamnionitis group）,there was no chorioamnionitis in the mother of 19 cases of premature infants（ non chorioamnionitis group）,the rate of chorioamnionitis was 40. 6（ 13 /32）. Among the 32 cases of premature infants,the brain injury occurred in 16 cases（ brain injury group）,there was no brain injury in 16 cases（ non brain injury group）,the rate of brain injury in preterm infants was 50. 0%（ 16 /16）. The rate of brain injury of preterm infants in chorioamnionitis group and non chorioamnionitis group was 76. 9%（ 10 /13） and 31. 6%（ 6 /19） respectively,the rate of brain injury of preterm infants in chorioamnionitis group was significantly higher than that in non chorioamnionitis group（ χ^2= 9. 743,P〈0. 05）. The level of IL-6 in umbilical artery blood in chorioamnionitis group and non chorioamnionitis group was（ 3. 76 ± 2. 58） and（ 0. 81 ± 0. 69） μg·L^-1 respectively,the level of IL-6 in umbilical artery blood in chorioamnionitis group was significantly higher than that in non chorioamnionitis group（ t = 11. 517,P〈0. 05）. The level of IL-6 in umbilical artery blood in brain injury group and non brain injury group was

关 键 词：早产儿 脑损伤 绒毛膜羊膜炎 白细胞介素-6 脐动脉血 

分 类 号：R722.6[医药卫生—儿科]