RND家族外排泵及其与微生物群体感应系统的相互关系  

RND efflux pump and its interrelationship with quorum sensing system

作　　者：梁志彬[1,2] 陈豫梅[1,2] 陈昱帆 程莹莹[2] 张炼辉[1,2] Zhibin Liang Yumei Chen Yufan Chen Yingying Cheng Lianhui Zhang(Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China)

机构地区：[1]华南农业大学群体微生物研究中心,广州510642 [2]广东省微生物信号与作物病害防控重点实验室,广州510642

出　　处：《遗传》2016年第10期894-901,共8页Hereditas（Beijing)

基　　金：国家重点基础研究发展计划项目(973计划)(编号:2015CB150600);国家自然科学基金项目(编号:31270170;31330002)资助~~

摘　　要：抗生素耐药性一直是细菌病害防治的难题,药物外排泵过量表达是细菌耐药性形成的重要机制之一。在革兰氏阴性细菌中,RND(Resistance-nodulation-cell division)家族外排泵在耐药性中发挥着重要作用,近年来的研究表明,依赖于小分子信号物质进行调控的群体感应系统与RND外排泵家族之间存在紧密的相互作用关系。本文在介绍RND家族外排泵的结构、转运机理和群体感应系统的类型及调控方式的基础上,剖析了群体感应系统对RND外排泵的调控机理以及RND外排泵对群体感应系统信号分子转运的影响。深入研究RND家族外排泵与群体感应系统之间的相互依赖、相互制约关系有利于阐明RND家族外排泵的调控机理,并有可能为克服微生物耐药性问题提供新的思路。Antibiotic resistance has become a serious concern in treatment of bacterial infections. Overexpression of efflux pump is one of the important mechanisms in antibiotic resistance. In Gram negative bacteria, RND（Resistance-nodulation-cell division） superfamily efflux pump plays a vital important role in antibiotics resistance. Recent research progress unveils an intriguing interrelationship between RND efflux pump and the bacterial quorum sensing system, whose regulation is dependent on small signal molecules. This article reviews the latest findings on the structure and transport mechanism of RND efflux pump, as well as the general features and regulatory mechanisms of quorum sensing, with a special focus on the role and mechanism of quorum sensing system in regulation of RND efflux pump, and the influence of efflux pump on quorum sensing signal transportation. Further investigation of the interrelationship between RND efflux pumps and the bacterial quorum sensing systems is critical for elucidation of the regulatory mechanisms that govern the expression of the RND efflux pumps genes, and may also provide useful clues to overcome the efflux pump mediated antibiotic resistance.

关 键 词：RND外排泵 群体感应 调控机理 信号转运 

分 类 号：R446.5[医药卫生—诊断学]