地塞米松磷酸钠注射液在预防唑来膦酸注射液急性期反应中的价值  

An evaluation of the effects of dexamethasone sodium phosphate injection in preventing acutephase reaction of zoledronic acid injection in elder osteoporotic women

作　　者：边平达[1] 寿张轩[2] 王珏[1] 应奇峰[1] 陈锦平[1] 

机构地区：[1]浙江省人民医院望江山院区骨质疏松诊疗中心,浙江杭州310024 [2]浙江省人民医院药学部,浙江杭州310014

出　　处：《中国骨质疏松杂志》2016年第10期1315-1317,共3页Chinese Journal of Osteoporosis

基　　金：浙江省医药卫生平台重点资助项目(2016ZDA002);浙江省人民医院优秀青年人员科研启动基金(zry2015C002)

摘　　要：目的为了探讨地塞米松磷酸钠注射液在减少老年女性骨质疏松症(OP)患者静脉滴注唑来膦酸注射液后急性期反应(APR)发生中的价值。方法把68例老年女性OP患者,随机分成2组,其中1组在静脉滴注唑来膦酸注射液5 mg前静脉推注地塞米松磷酸钠注射液5 mg,然后比较两组患者72 h内在发热、流感样症状、肌痛、头痛头晕、失眠、恶心呕吐等APR发生率上差异。结果两组患者72 h内在发热、流感样症状、肌痛、头痛头晕、失眠、恶心呕吐等症状发生率上的差异无统计学意义(P>0.05)。结论静脉推注地塞米松磷酸钠注射液,不能降低老年女性OP患者静脉滴注唑来膦酸注射液后APR的发生率。Obje ctive To evaluate the effects of dexamethasone sodium phosphate injection as a preventive procedure against acute-phase reaction（ APR） of zoledronic acid injection in elder osteoporotic women. Me thods A total of 68 elder osteoporotic women were randomized to either standard treatment group（ n = 34,zoledronic acid injection,5mg,intravenous infusion） or dexamethasone group（ n = 34,dexamethasone sodium phosphate injection 5 mg,push intravenous injection,and zoledronic acid injection,5mg,intravenous infusion）. APR（ ≤ 72 h after infusion）,including pyrexia,influenza-like symptoms,myalgia,headache,swirl,insomnia,nausea and vomiting,etc. were compared between the two groups. Re sults There were no significant differences in APR between the standard treatment group and dexamethasone group（ P 〉 0. 05）. Conclusions Dexamethasone sodium phosphate injection could not to prevent against APR of zoledronic acid injection in osteoporotic women.

关 键 词：唑来膦酸 地塞米松 骨质疏松症 急性期反应 

分 类 号：R591.44[医药卫生—内科学]