分子信号通路在骨质疏松症发生机制中的研究进展  

Research progress in molecular signaling pathways on the pathogenesis of osteoporosis

作　　者：闫慧明[1] 郭静[2] 安燕[1] 张雪[1] 

机构地区：[1]包头医学院第二附属医院风湿免疫科,内蒙古包头014030 [2]包头市中心医院,内蒙古包头014040

出　　处：《中国骨质疏松杂志》2016年第10期1336-1340,共5页Chinese Journal of Osteoporosis

摘　　要：目的骨质疏松症正成为影响老年人健康的老年疾病之一,主要原因是骨吸收大于骨形成,成骨细胞数量减少和活性下降。目前研究重点主要通过调节骨合成代谢的信号传导通路,抑制破骨细胞骨吸收,降低骨转换以达到减少骨量丢失。本文总结了骨代谢相关调控通路,包括MAPK信号转导途径、Notch信号通路、Wnt/-catenin信号途径、BMPs信号通路、PPAR-r信号通路、TGF-信号通路和Hedgehog信号转导途径。多个信号通路相互交叉,共同参与通路中相关因子的调节,通过激活或抑制一些关键环节的细胞因子,在骨代谢过程中发挥了主要作用。Osteoporosis is becoming one of the major diseases in old age. It affects the health of the elderly,and was caused by greater bone absorption than bone formation. Current research is focused on regulating bone anabolic signal transduction pathways,inhibiting osteoclast bone absorption,and reduce bone remodeling to reduce bone loss. This article summarizes bone metabolism related regulation pathways, including the MAPK signal transduction pathways, Notch signal pathway, Wnt / decide- catenin signaling pathways,BMPs signaling pathways,PPAR-r signaling pathways,TGF-decide signaling pathways and Hedgehog signal transduction pathways. Multiple signaling pathways cross each other, participate in the regulation of relevant factors in the pathways,through activating or inhibiting cytokines at some key links,and play a major role in bone metabolism.

关 键 词：骨质疏松症 信号通路 进展 机制 

分 类 号：R68[医药卫生—骨科学]