无症状高尿酸血症对患者膝关节置换术后功能恢复的影响  

Effect of asymptomatic hyperuricemia on the postoperative functional recovery in patients with knee joint replacement

作　　者：杨志奎[1] 代加楠[1] 曹熙[1] 李永刚[1] 李鹏[1] 高鑫[1] 刘冲[1] 

机构地区：[1]延安大学咸阳医院骨科,陕西咸阳712000

出　　处：《局解手术学杂志》2016年第11期834-837,共4页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的分析无症状高尿酸血症对患者膝关节置换术后功能恢复的影响,明确尿酸水平对膝关节置换术后患膝功能恢复的影响。方法 2013年2月至2015年9月本院膝关节置换患者294例,根据纳入标准和排除标准,随访结束后剩余187例,按术前高尿酸血症的诊断标准分为对照组108例和高尿酸组79例。比较2组患者在术前、术后2周、术后3个月以及术后6个月的WOMAC骨关节炎评分的差异。利用多元线性回归分析各因素对WOMAC评分变化值的影响。结果术后2周2组患者的WOMAC评分均显著提高,与术前比较差异具有统计学意义(P<0.05)。术后2周及术后3个月,对照组WOMAC评分高于高尿酸组,差异具有统计学意义(P<0.05)。结论术前血尿酸水平是影响WOMAC评分的因素。膝关节置换术前尿酸水平偏高对术后功能改善具有不利影响。Objective To evaluate the effect of asymptomatic hyperuricemia on the postoperative functional recovery in osteoarthritis（ OA） patients with knee joint replacement. Methods Among the 294 patients who recieved knee joint replacement in our hospital from February 2013 to September 2015,a total of 187 patients were included in this study with 79 cases in the hyperuricemia group and the other 108 cases in the control group. The WOMAC index of the two groups were analyzed before the surgery,2 weeks,3 months,and 6 months after the knee joint replacement surgery. Multivariable linear regression was performed to test the effect of impact factors on the variation of WOMAC index. Results The WOMAC index of the two groups significantly increased 2 weeks after surgery,and the difference was statistically significant（ P〈0. 05）. And the WOMAC index of the control group was higher than that in the hyperuricemia group 2 weeks and 3 months after surgery with statistically significant difference（ P〈0. 05）. Conclusion The uric acid level before surgery was a influence factor of WOMAC index,and high uric acid level before knee joint replacement has negatively impact for the postoperative functional recovery in the osteoarthritis patients.

关 键 词：尿酸 膝关节置换术 骨关节炎 WOMAC评分 

分 类 号：R684.3[医药卫生—骨科学]