5-氨基酮戊酸光动力作用对白念珠菌超微结构的影响  

Influence of 5-aminolevulinic Acid Photodynamic on Ultrastructure of Candida Albicans

作　　者：张子平[1] 钟熙[1] 程波[1] 苏惠春[1] 陈丽红[1] 

机构地区：[1]福建医科大学附属第一医院皮肤科,福州350005

出　　处：《福建医科大学学报》2016年第4期260-263,共4页Journal of Fujian Medical University

基　　金：福建省中青年教师教育科研项目(JB13394)

摘　　要：目的观察5-氨基酮戊酸光动力对白念珠菌细胞超微结构的影响,为研究5-氨基酮戊酸光动力抗菌的作用机制提供理论基础。方法设置实验组(5-氨基酮戊酸光动力作用后的白念珠菌组)及对照组,分别在透射电镜下观察2组菌株细胞的超微结构。结果透射电镜下,5-氨基酮戊酸光动力作用后的白念珠菌细胞肿胀变形,细胞壁、细胞膜结构不完整,细胞壁疏松,细胞膜与细胞壁之间间隙大小不一,部分细胞可见细胞壁棉絮状致密外层或细胞膜局灶性缺失的现象。结论 5-氨基酮戊酸光动力对白念珠菌的细胞壁结构具有一定的影响。Objective To observe the influence of 5-aminolevulinic acid photodynamic on ultra-structure of Candida albicans and to provide a theoretical basis forstudyingantifungal mechanism of ALA-PDT . Methods Ultrastructure of Candida albicans in experimental group（subjected to 5-aminolevulinic acid photodynamic）and in control group were observed under transmission electron microscope . Results Under transmission electron microscope ,the cells ,after being subjected to 5-aminolevulinic acid photodynamic ,presentedswelling deformation ,showing incomplete walland membrane structure . The cell wall was loose ,and the gap between the cell membrane and cell wall varied in sizes . We also observed ,in some cells ,incomplete cell wall structure with electron dense layers and cell membrane discontinuation at localized area . Conclusions 5-aminolevulinic acid photodynamic may play a role in the structure of cell wall of Candida albicans .

关 键 词：氨基酮戊酸 光化学疗法 念珠菌 白色 显微镜检查 电子 透射 

分 类 号：R379.4[医药卫生—病原生物学] R453[医药卫生—基础医学]