特异性免疫治疗对儿童过敏性鼻炎-哮喘综合征的效果观察  

Effect of Specific Immunity in Treatment of Children with Allergic Rhinitis Combined with Asthma

作　　者：王淑玉[1] 郑一博[1] 吕朝霞[1] 

机构地区：[1]解放军白求恩国际和平医院儿科,石家庄050082

出　　处：《解放军医药杂志》2016年第10期65-68,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：解放军白求恩国际和平医院计划重点课题(201508)

摘　　要：目的探讨特异性免疫治疗对过敏性鼻炎-哮喘综合征(combined allergic rhinitis and asthma syndrome,CARAS)儿童的临床效果和肺功能改善情况。方法选择2014年2月—2015年2月就诊的CARAS 85例。按治疗方法分为观察组40例和对照组45例。对照组给予吸入糖皮质激素治疗,观察组在对照组基础上给予特异性免疫治疗。观察两组哮喘控制测试(C-ACT)、过敏性鼻炎症状评分及肺功能变化情况。结果治疗后12个月观察组C-ACT评分高于对照组,治疗9、12个月观察组鼻炎症状评分低于对照组(P<0.05)。观察组治疗9、12个月第1秒用力呼气量、用力呼出50%肺活量的呼气流速、用力呼出75%肺活量的呼气流速、最大呼气中期流量较对照组升高,呼吸总阻抗、气道总阻力、周边弹性阻力绝对值较对照组降低(P<0.05,P<0.01)。结论特异性免疫治疗联合吸入糖皮质激素治疗CARAS效果优于单纯吸入糖皮质激素,能显著改善小气道功能。Objective To investigate effect of specific immunity in treatment of children with allergic rhinitis combined with asthma（ CARAS） and improvement of pulmonary function. Methods A total of 85 CARAS children were divided into observation group（ n = 40） and control group（ n = 45） according to treatment method. Control group received treatment of glucocorticoids inhalation,while observation group received specific immunity on the basis of treatment for control group. Changes of asthma control test（ C-ACT） score,allergic rhinitis symptoms and pulmonary function were observed in two groups. Results After treatment,in observation group,C-ACT score was higher 12 months after treatment,and scores of allergic rhinitis symptoms were lower 9 and 12 months after treatment than those in control group（ P〈0. 05）. In observation group,values of forced expiratory volume in the first second,forced expiratory flow 50%,forced expiratory flow 75% and maximal midexpiratory flow were increased 9 and 12 months after treatment,while values of totally respiratory impedance,total airway resistance and absolute value of peripheral elastic resistance were decreased compared with those in control group（ P〈0. 05,P 〈0. 01）. Conclusion Specific immunity combined with of glucocorticoids inhalation in treatment of children with CARAS can achieve better effect and well improve small airway function compared with those by therapy of hormonal inhalation only.

关 键 词：免疫疗法 鼻炎 变应性 常年性 哮喘 治疗结果 儿童 

分 类 号：R725.6[医药卫生—儿科]