克林霉素联合复方磺胺甲噁唑片治疗艾滋病合并肺孢子菌肺炎的疗效分析  

Therapeutic effect of clindamycin combined with compound sulfamethoxazole tablets on pneumocystis pneumonia associated with acquired immunodeficiency syndrome

作　　者：陈钟[1] 肖钢 周泉[1] 何艳[1] 

机构地区：[1]中南大学湘雅二医院,湖南长沙410011 [2]长沙市第一医院,湖南长沙410005

出　　处：《中国感染控制杂志》2016年第10期773-776,共4页Chinese Journal of Infection Control

基　　金：湖南省发改委科研计划项目(湘财企指2015-83)

摘　　要：目的：了解克林霉素联合复方磺胺甲口恶唑片治疗艾滋病合并肺孢子菌肺炎（PCP）的治疗效果。方法收治2014年1月—2015年3月某院艾滋病合并 PCP 患者97例，根据治疗方案不同分为对照组（给予复方磺胺甲口恶唑片进行治疗，49例）和实验组（在对照组治疗基础上加入克林霉素进行治疗，48例），记录治疗前后两组患者血氧指标－动脉血氧分压（PaO2）、动脉血氧饱和度（SaO2）水平、血清清蛋白（ALB）和血乳酸脱氢酶（LDH）等水平变化。结果两组患者治疗前血氧指标 PaO2、SaO2、ALB 和 LDH 水平比较，差异无统计学意义（均 P ＞0．05）。治疗后对照组和实验组的 PaO2分别为（73．01±4．62）mmHg、（84．92±5．34）mmHg，SaO2分别为（75．81±4．28）％、（90．86±5．94）％，ALB 分别为（32．62±4．41）g／L、（43．95±5．03）g／L，LDH 分别为（416．53±30．77） U／L、（331．58±20．86）U／L，治疗后实验组 PaO2和 SaO2水平均高于对照组，实验组和对照组 ALB 和 LDH 水平比较，差异均有统计学意义（均 P ＜0．05）。实验组总有效率为89．58％（43例），高于对照组的69．39％（34例），差异有统计学意义（χ2＝6．04，P ＝0．014）。结论克林霉素联合复方磺胺甲口恶唑片对艾滋病合并 PCP 患者具有良好的治疗效果，值得临床推广和应用。Objective To understand the therapeutic effect of clindamycin combined with compound sulfamethoxazole tablets on pneumocystis pneumonia（PCP）associated with acquired immunodeficiency syndrome （AIDS）.Methods 97 AIDS patients with PCP in a hospital from January 2014 to March 2015 were randomly divided into control group （n=49,received compound sulfamethoxazole ）and trial group（n=48,received clindamycin on the basis of com-pound sulfamethoxazole ）,levels of partial pressure of oxygen in arterial blood （PaO2 ）,arterial blood oxygen satu-ration（SaO2 ）,serum albumin（ALB）,and lactic dehydrogenase （LDH）in two groups of patients before and after treatment were recorded.Results Levels of PaO2 ,SaO2 ,ALB,and LDH between two groups of patients before treatment was not significantly different（all P 〉0.05）.After treatment,PaO2 in control group and trial group were （73.01 ±4.62）mmHg and（84.92 ±5.34）mmHg respectively,SaO2 were （75.81 ±4.28）% and（90.86 ±5.94）%respectively,ALB were （32.62±4.41 ）g/L and（43.95 ±5.03）g/L respectively,LDH were（416.53 ±30.77）U/L＆nbsp;and（331 .58±20.86）U/L respectively,levels of PaO2 and SaO2 in trial group were both higher than control group , difference in ALB and LDH between two groups of patients after treatment were both statistically significant（both P 〈0.05）.The total effective rate of trial group was 89.58% （n=43）,which was higher than 69.39%（n=34）in control group （χ2 =6.04,P =0.014）.Conclusion Clindamycin combined with compound sulfamethoxazole tablets has good therapeutic effect on AIDS and PCP,which is worthy of clinical popularization and application.

关 键 词：克林霉素 复方磺胺甲唑片 艾滋病 肺孢子菌肺炎 疗效 

分 类 号：R512.91[医药卫生—内科学]