急性白血病患者口腔感染直接经济损失分析  

Direct economic loss due to oral infection in acute leukemia patients

作　　者：刘芸宏[1] 王书会[1] 王静娜[1] 吴晓慧[1] 李颖霞[1] 

机构地区：[1]山东大学齐鲁医院,山东济南250012

出　　处：《中国感染控制杂志》2016年第10期785-787,共3页Chinese Journal of Infection Control

基　　金：山东省科技发展计划项目(2013GSF11801)

摘　　要：目的了解急性白血病(AL)患者口腔感染所致的直接经济损失。方法对2011年1月—2013年12月山东省某三级甲等医院血液病房AL口腔感染患者进行调查,采用病例对照的方法进行1︰1配对,比较口腔感染组(病例组)与未感染组(对照组)AL患者的住院费用及住院日数等情况。结果共监测AL患者994例,发生医院感染277例,其中口腔感染17例(5.56%)。病例组患者住院费用中位数为37 327元,对照组为13 176元,病例组患者总住院费用是对照组的2.83倍,差异具有统计学意义(Z=-3.621,P<0.001)。病例组各项住院费用均高于对照组,住院费用增加最多的是西药费、输血费、化验费和治疗费。病例组住院日数中位数为17 d,对照组为11 d,经秩和检验,两组患者住院日数中位数比较,差异具有统计学意义(Z=-3.627,P<0.001)。结论 AL患者发生口腔感染后导致住院费用增加,住院日数延长,增加了患者的经济负担。Objective To investigate the direct economic loss caused by oral infection in patients with acute leuke-mia.Methods Acute leukemia patients with oral infection in a tertiary first-class hospital in Shandong Province be-tween January 2011 and December 2013 were investigated,the 1 ：1 matched case-control method was used for com-paring hospitalization expense and length of hospital stay between oral infected （case group）and uninfected patients （control group ）.Results A total of 994 patients with acute leukemia were monitored,277 had healthcare-associated infection,17 （5.56%）of whom were with oral infection.The median hospitalization expense of patients in case group and control group was￥37 327 and￥13 176 respectively,the total hospitalization expense of patients in case group was 2.83 times more than control group,difference was statistically significant （Z = -3.621 ,P 〈0.001）.Each hospitalization expense of case group was higher than control group,especially expense for medicine, blood transfusion,laboratory examination,and therapy.The median length of hospital stay in case group and con-trol group were 17 days and 11 days respectively,rank sum test showed that difference in median length of hospital stay between two groups was statistically significant （Z =-3.627,P 〈 0.001 ）.Conclusion Acute leukemia pa-tients with oral infection have increased hospitalization expense,prolonged length of hospital stay,and increased the financial burden.

关 键 词：急性白血病 白血病 口腔感染 医院感染 直接经济损失 

分 类 号：R181.32[医药卫生—流行病学]