皮肤性病门诊生殖道酵母菌阳性结果分析  

Identification and drug sensitivity of pathomycetes isolated from patients in dermato-venereal clinic

作　　者：唐三梅 吴兴中[1] 黄进梅[1] 

机构地区：[1]广东省皮肤性病防治中心,广东广州510091

出　　处：《中国微生态学杂志》2016年第10期1197-1200,共4页Chinese Journal of Microecology

摘　　要：目的探讨生殖道假丝酵母菌阳性率、药敏情况及耐药趋势,为临床合理选用抗真菌药物提供最新的依据。方法按照《全国临床检验操作规程》,采用法国梅里埃生物公司API-20C酵母菌鉴定板、ATB-Fungus酵母菌药敏板对2012年1月至2014年12月培养生殖道酵母菌阳性的标本进行鉴定及药敏试验。结果 1 419例生殖道分泌物分离出114例假丝酵母菌,感染率为8.0%,其中白假丝酵母菌101例占88.60%,感染率最高,其他非白假丝酵母菌13例占11.40%;药敏结果表明,假丝酵母菌对5-氟胞嘧啶、两性霉素B具有较高敏感性(92.11%、100.00%),对氟康唑、伊曲康唑、伏立康唑呈现不同程度的耐药;101例白假丝酵母菌对5-氟胞嘧啶、两性霉素B的敏感性分别为93.07%、100.00%,未出现对两性霉素B的耐药菌株。结论皮肤性病门诊生殖道酵母菌分离株仍以白假丝酵母菌为主,白假丝酵母菌对氟康唑、伊曲康唑、伏立康唑的耐药率呈上升趋势;微生物实验室应加强对假丝酵母菌的分离鉴定及耐药性监测,为临床医生准确合理地使用抗真菌药物提供病原学依据。Objective To analyze the positivity rate,drug sensitivity and resistence trends of Candidacausing genital candidiasis and provide up-to-date evidence for clinical treatment.Methods Identification and drug sensitivity test were performed on the samples with positive result of Candidaculture during Jan.2012 and Dec.2014 by using API 20 Cand ATB Fungus 3in accordance with′The National Technical Procedure Manual in Clinical Laboratory′.Results One hundred and fourteen strains of Candidas were isolated from1 419 STD patients,the positive rate was 8.0%.In these strains,there were 101 strains of Candida albicans（88.60%）and 13 strains of other Candidaspecies.The Candida strains were highly susceptible to amphotericin B（100%）and 5-fluorocytosine（92.11%）,while resistant to fluconazole,itraconazole and voriconazole to different extent.The sensitivity rates of the 101 strains of Candida albicans to AMB and 5-FC were 100.00% and 93.07%,respectively;no AMB-resistant strains were detected.Conclusion The main clinical pathomycete strains causing urogenital candidiasis were Candida albicans,the resistance rates of which to FCA,ITR and VRC showed an upward trends.Microbiological lab should focus on the identification and resistance monitoring on Candidas so as to provide accurate information for proper antifungal treatment in clinical practices.

关 键 词：生殖道 假丝酵母菌 耐药性 

分 类 号：R379[医药卫生—病原生物学]