复方沙棘籽油栓改善阴道微生态环境的临床试验研究  

Compound sea buckthorn seed oil suppository improves the microecological environment of vagina

作　　者：张岱[1] 林怀宪[1] 刘朝晖[1] 耿力[2] 王威[2] 夏蓓[3] 王冬娜[3] 廖秦平[1] 

机构地区：[1]北京大学第一医院妇产科,北京100034 [2]北京大学第三医院妇产科,北京100191 [3]首都医科大学宣武医院妇产科,北京100053

出　　处：《中国微生态学杂志》2016年第10期1201-1205,共5页Chinese Journal of Microecology

基　　金：国家自然科学基金(81471420)

摘　　要：目的研究中成药复方沙棘籽油栓调节微生态环境对治疗外阴阴道假丝酵母菌病合并菌群紊乱的临床意义。方法采用多中心、前瞻性、随机、剂量组平行对照临床试验,分为氟康唑组和联合应用氟康唑及复方沙棘籽油栓组,在停药的第(7±3)天和4周±5天分别随访患者一次,观察症状及实验室检查等方面的变化,采用Nugent评分进行微生态改善及疗效评价。结果有64名妇女进入研究,其中氟康唑组31例,联合组33例。两组患者入组时各项指标无显著性差异。两组患者之间入组、第一次随访的pH值均无显著性差异,但是在第二次随访中显示氟康唑组的pH值(4.42±0.48)显著高于联合组(4.09±0.39),P<0.05。入组氟康唑组的Nugent评分(6.26±1.29)与联合组(6.18±1.21)无显著差异,第一次随访两组Nugent评分有显著差异,氟康唑组(4.55±1.84)、联合组(3.39±1.44),P<0.05。在第二次随访时,氟康唑组的Nugent评分(4.84±1.85)显著高于联合组(3.06±1.63),P<0.05。第二次随访,单用氟康唑组真菌复发率高于联合组(13/31,41.9%vs 5/33,15.2%,P=0.017)。结论复方沙棘籽油栓可以改善阴道微生态环境,联合氟康唑治疗外阴阴道假丝酵母菌病合并菌群紊乱较单用氟康唑组比较,阴道微生态环境恢复好,真菌复发率低。Objective To study the clinical effect of compound sea buckthorn seed oil suppository in regulating vaginal microecological environment and in treatment of vulva vaginal candidiasis complicated with abnormal vaginal flora.Methods A multicenter,prospective,randomized,dose group parallel controlled clinical trial was conducted.The patients were divided into the fluconazole group（fluconazole alone）or combination group（fluconazole combined with compound sea buckthorn seed oil suppository）.Both groups were followed up at Day 7±3and 4weeks± 5days.Nugent score was used to evaluate the change of vaginal flora.Results Sixty-four women were included in the study,31 cases in fluconazole group,33 cases in combination group.There was no significant difference between the two groups at baseline.The pH value of fluconazole group was higher than that of combination group（4.42±0.48 vs 4.09±0.39,P〈0.05）at the second follow-up.At both follow-up,the Nugent scores of fluconazole group were higher than that of combination group（4.55±1.84 vs 3.39±1.44,4.84±1.85 vs 3.06±1.63,P〈0.05）.The fungal recurrence rate of fluconazole group was higher than that of combination group at the second follow-up（13/31,41.9%vs 5/33,15.2%,P=0.017）.Conclusion Compound sea buckthorn seed oil suppository can improve the vaginal microenvironment.Combination of fluconazole and compound sea buckthorn seed oil suppository is superior to fluconazole alone in the treatment of VVC complicated with abnormal vaginal flora,which can restore vaginal microecological environment more effectively and lower fungal recurrence rate.

关 键 词：外阴阴道假丝酵母菌病 菌群紊乱 阴道微生态 微生态疗法 

分 类 号：R711.31[医药卫生—妇产科学]