肠道菌群与脑-肠轴相互作用关系研究进展  

Interaction between gut microbiota and brain-gut axis:Research progress

作　　者：孙波[1,2] 陈亭[1] 王婷[1] 胡琛 朱京慈[1] 

机构地区：[1]中国人民解放军第三军医大学护理学院基础护理学教研室,重庆400038 [2]山东大学齐鲁医院,山东济南250012

出　　处：《中国微生态学杂志》2016年第10期1206-1211,共6页Chinese Journal of Microecology

基　　金：国家自然科学基金面上项目(81272079)

摘　　要：人体肠道内定植了大量的细菌,它们参与机体多种生理功能的维持。大脑与胃肠道之间通过脑-肠轴进行双向关联。近年研究发现肠道菌群与脑-肠轴可相互作用、相互影响。肠道菌群可影响机体神经内分泌系统及免疫系统的功能,脑-肠轴功能变化同样也会改变肠道的菌群结构。本研究就肠道菌群与脑-肠轴功能相互影响的研究进展作一综述,以期为深入了解肠道菌群对脑-肠轴功能的影响提供参考。The intestinal tract of mammals is inhabited by hundreds of microbiota,which plays roles in the maintenance of lots of physiological functions.The brain and the gastrointestinal tract are engaged in constant bi-directional communication through the brain-gut axis.Recent researches reported that gut microbiota and the brain-gut axis could interact and influence each other.Gut microbiota can influence the functions of neuroendocrine system and the immune system.Changes in function of the brain-gut axis will also alter the structure of intestinal flora.This article reviewed the advances in studies on the interaction between gut microbiota and brain-gut axis,with the intention of providing a reference for further understanding of the influence of gut microbiota on the brain-gut axis.

关 键 词：肠道菌群 脑-肠轴 神经系统 下丘脑-垂体-肾上腺轴 

分 类 号：R37[医药卫生—病原生物学]