FibroScan与慢性乙型肝炎肝组织炎症及纤维化程度的相关性研究  

The correlection research between Fibroscern and the degree of liver inflammation and fibrosis

作　　者：李振挺 李芹[1] 林恢[2] 陈达[2] 

机构地区：[1]福建中医药大学 [2]福州市传染病医院

出　　处：《中西医结合肝病杂志》2016年第5期270-271,274,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金："十二五"国家重大科技专项(No.2013ZX10005002-001)

摘　　要：目的:通过分析FibroScan与肝组织炎症及纤维化程度的相关性,FibroScan值与APRI(AST/PLT)、HBV DNA、AFP相关性,对比FibroScan与APRI诊断肝纤维化的优劣,为临床使用FibroScan检测辅助诊断乙肝肝纤维化提供循证依据。方法:选择82例符合纳入标准的患者,予以FibroScan检查及肝脏穿刺活检方法检测炎症、纤维化程度,同时检测患者的AST、PLT、HBV DNA、AFP,用SPSS 18.0软件对实验数据进行统计。结果:FibroScan值随纤维化程度增大而逐渐增大(P<0.01),4期间差异有显著性意义(P<0.01)。FibroScan值与肝脏组织病理分期(炎症、纤维化)、APRI值呈正相关(P<0.01)。与HBV DNA、AFP之间不相关(P值分别为0.986和0.163)。FibroScan的纤维化评价优于APRI值。结论:FibroScan检测可在一定程度上准确评估肝纤维化程度及炎症程度,能替代部分肝活检检查。因其无创、简便、经济的优势,对患者无疑是更加满意的选择,同时,对临床早期诊断肝硬化也具有重要意义。Objective： To Analyze the correlation between FibroScan and the degree of liver inflammation and fibrosis, Analysing the corela- tion between liver stiffness measure （FibroScan） and APRI （AST/PLT）, HBV DNA, AFP to provide evidences for diagnosing chronic hepatitis B by Fibroscan in clinical practice. Methods：Choosing 82 samples who meet the standards and giving them both Fibroscan and the liver needle biopsy to diagnose liver inflammation and the grade of fibrosis degree in chronic hepatitis B. Meanwhile we test the level of patients＇ AST,PLT, HBV DNA, AFP and compile the statistics by using SPSS 18.0 software. Results：liver stiffness measure （FibroScan） increases with the degree of fibrosis （ P 〈 0. 01 ）. Four phases＇ difference was statistically significant （ P 〈 0. 01 ）. There was a positive correlation between the liver stiffness measure（FibroScan） and liver tissue pathology classification. There was no relation between HBV DNA, AFP. FibroScan fibrosis assessment was better than that of APRI values. Conclusion： FibroScan detection could accurate asses liver inflammation and the grade of fibrosis degree and re- place part of the liver needle biopsy. Patients are satisfied with Fihroscan because of its advantages of noninvasive, convenient and economic. At the same time, it has important significance for early clinical diagnosis of liver cirrhosis.

关 键 词：乙型肝炎 肝纤维化 肝弹性硬度 相关性 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]