微RNA与慢性肾脏病血管钙化机制的研究进展  

Research Progress of MicroRNAs in Vascular Calcification Mechanisms in Chronic Kidney Disease

作　　者：邢莹[1] 郝丽荣[1] 

机构地区：[1]哈尔滨医科大学附属第一医院肾内科

出　　处：《医学综述》2016年第20期3984-3987,共4页Medical Recapitulate

摘　　要：慢性肾脏病(CKD)及终末期肾脏疾病患者有较高的心血管疾病发病率,主要原因是血管钙化。与骨形成有很多相似之处,血管钙化是一个主动的可调节进程。最近关于血管钙化的研究发现,微RNA(miRNA)与启动和促进CKD患者血管钙化的机制有关。miRNA在调节细胞表型、钙磷平衡及基质小囊泡中起重要作用,并影响CKD患者的血管钙化。这种miRNA在血管钙化方面的重要作用对未来CKD和终末期肾脏疾病患者血管钙化进行生物标记及治疗方法的探索有重要意义。Patients with chronic kidney disease（CKD） and end stage renal disease have significant cardiovascular morbidity and mortality due to vascular calcification. Vascular calcification is an active, highly regulated process that has many similarities with bone formation. Recent discoveries revealed that microRNA （miRNA） is involved in the initiation and progression of vascular calcification in CKD. miRNA regulates vascular calcification through controlling cell phenotype, calcium and phosphorous homeostasis and matrix vesicles. The important role of miRNA in vascular calcification is of great significance for the development of biomarkers and therapeutic options for patients with CKD and end stage renal disease.

关 键 词：慢性肾脏病 微RNA 血管钙化 细胞外基质囊泡 

分 类 号：R543.5[医药卫生—心血管疾病]