胱抑素C在慢性肾脏病肾功能评估和预后预测中的价值  

The value of cystatin C in functional assessment and prognosis prediction in patients with chronic kidney disease

作　　者：王霞[1] 王金泉[1] 

机构地区：[1]南京军区南京总医院肾内科、国家肾脏疾病临床医学研究中心、全军肾脏病研究所,南京210016

出　　处：《解放军医学杂志》2016年第10期874-878,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家“十二五”科技支撑计划课题(2015BAll2805)~~

摘　　要：肾小球滤过率的准确检测和估算是慢性肾脏病(CKD)分期的重要依据,依据血清肌酐估算肾小球滤过率是临床上常用的方法,但存在一定局限性。新近研究表明,胱抑素C能更为准确地评估CKD患者的肾功能,更好地预测全因死亡率、心血管死亡和终末期肾病的风险。本文就胱抑素C在CKD肾功能评估和预后预测中的价值综述如下。Accurate measurement and estimation of glomerular filtration rate（GFR） is a key indicator for early diagnosis and accurate classification of chronic kidney diseases（CKD）. Serum creatinine measurement is a common method for estimating GFR, however, its clinical use remains very limited. Recent studies demonstrate that cystatin C has been used extensively as a research tool for evaluation of renal function in CKD patients, and can more accurately predict all-cause mortality, cardiovascular morbidity and mortality and the risk for end-stage renal disease. This article reviews the value of cystatin C in functional assessment and prognosis prediction in CKD patients.

关 键 词：半胱氨酸蛋白酶抑制物C 慢性肾脏病 肾小球滤过率 

分 类 号：R692[医药卫生—泌尿科学]