慢性阻塞性肺疾病患者血浆氨基末端脑钠肽前体检测的临床意义  

Clinical significance of plasma N-terminal pro-brain natriuretic peptide detection in patients with chronic obstructive pulmonary diease

作　　者：沈文富[1] 李红苗[1] 姜正华 SHEN Wenfu LI Hongmiao JIANG Zhenghua(Department of Respiratory Diseases, Jianhu Hospital, Jianhu 224700, CHIN)

机构地区：[1]建湖县人民医院呼吸病科,江苏省224700 [2]苏北人民医院呼吸病科

出　　处：《江苏医药》2016年第20期2235-2237,共3页Jiangsu Medical Journal

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者血浆氨基末端脑钠肽前体(NT-proBNP)检测的临床意义。方法采用双抗体夹心免疫荧光法检测COPD急性加重期(A组,52例)、COPD稳定期(B组,29例)患者和健康体检者(C组,22例)血浆NT-proBNP水平。结果 A组血浆NT-proBNP为(1046.06±746.62)pg/ml,高于B组的(138.24±51.49)pg/ml和C组的(15.05±10.66)pg/ml(P<0.05),B组血浆NT-proBNP高于C组(P<0.05)。结论 COPD患者血浆NT-proBNP水平明显高于常人,COPD急性加重期患者血浆NT-proBNP增高更为明显,可作为评估COPD患者病情的敏感指标。Objective To investigate the clinical significance of plasma N‐terminal pro‐brain natriuretic peptide （NT‐proBNP） detection in patients with chronic obstructive pulmonary dieases （COPD） .Methods With double antibody sandwich immunoassay ,plasma level of NT‐proBNP was detected in COPD patients with acute attack （group A ,52 cases） ,with stable COPD （group B ,29 cases） and healthy people（group C ,22 cases） .Results Plasma NT‐proBNP in group A was （1046.06 ± 746.62） pg/ml ,which was significantly higher than （138.24 ± 51.49） pg/ml in group B and （15.05 ± 10.66） pg/ml in group C （P〈0 .05） .Plasma level of NT‐proBNP in group B was significantly higher than that in group C （ P〈0 .05 ） .Conclusion Compared to healthy people ,plasma level of NT‐proBNP is significantly elevated in COPD patients ,especially in acute attack stage ,and may be taken as a sensitive indicator in evaluating the illness of COPD .

关 键 词：慢性阻塞性肺疾病 氨基末端脑钠肽前体 

分 类 号：R563[医药卫生—呼吸系统]