空腹生长抑素对2型糖尿病外周动脉疾病的影响及机制初步探讨  

Effect of fasting somatostatin levels on type 2 diabetic peripheral arterial disease and its mechanisms

作　　者：褚加成[1] 孙明谨[1] 陆春丽[1] 白弘波 

机构地区：[1]湖北医药学院附属随州医院内分泌科,湖北随州441300

出　　处：《实用药物与临床》2016年第10期1244-1246,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的 探讨空腹血清生长抑素（FSS）与2型糖尿病外周动脉疾病（PAD）的关系。方法 根据踝臂指数（ABI）,将120例2型糖尿病患者分为无外周动脉疾病组（A组,82例,ABI值为1.0~1.4）和外周动脉疾病组（B组,38例,ABI〈0.9）,检测FSS、胰岛素样生长因子-1（IGF-1）水平。结果 B组的FSS水平（pg/L）低于A组（28.24±5.01 vs.37.23±6.19）,IGF-1（ng/mL）高于A组（219.17±24.97 vs.157.91±27.71）,差异均有统计学意义（P〈0.05）。Logistic回归分析显示,年龄、收缩压、舒张压、FSS、IGF-1、三酰甘油、低密度脂蛋白是与2型糖尿病外周动脉疾病密切相关的影响因素（P〈0.05）。结论 FSS与PAD密切相关,生长抑素可能为2型糖尿病外周动脉疾病患者的保护因素,其机制可能与抑制IGF-1作用有关。Objective To investigate the relationship between fasting serum somatostatin（FSS） and peripheral arterial disease（PAD） in patients with type 2 diabetes（T_2DM）.Methods According to the ankle-brachial index（ABI）,120 patients with type 2 diabetes were divided into no peripheral arterial disease group（group A,n = 82,ABI1.0- 1.4） and peripheral arterial disease group（group B,n = 38,ABI 0.9）.The levels of FSS and IGF-1 were detected in the two groups.Results Group B has lower level of FSS than group A[（28.24 ±5.01） pg/L vs.（37.23 ±6.19） pg/L,P0.05]and higher level of IGF-1[（219.17 ±24.97） ng/mL vs.（157.91 ±27.71） ng/mL,P 〈0.05].Logistic regression analysis showed that age,systolic blood pressure,diastolic blood pressure,FSS,IGF-1,triglycerides and LDL-c were influential factors which were closely related to peripheral arterial disease in patients with type 2 diabetes（P 〈0.05）.Conclusion FSS is closely related to PAD,and SS may be the protective factor for peripheral arterial disease in patients with type 2 diabetes,which may be related to inhibiting the function of IGF-1.

关 键 词：生长抑素 2型糖尿病 外周动脉疾病 

分 类 号：R587.2[医药卫生—内分泌] R543.5[医药卫生—内科学]