血小板在组织修复中作用的研究进展  

Research Progress on Roles of Platelets in Tissue Repair——Review

作　　者：吴宇璐[1] 乔建林 徐开林[1] 曾令宇[1] 

机构地区：[1]徐州医学院血液病研究所,江苏徐州221002

出　　处：《中国实验血液学杂志》2016年第5期1603-1606,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金(81400082;81370602);江苏省自然科学基金(BK2012573;BK20140219)

摘　　要：血小板在血栓和止血中发挥着举足轻重的作用。近些年来研究显示,血小板除在止凝血中发挥作用之外,还参与了体内组织修复和再生。随着对血小板在组织修复中的研究,大量的实验研究证实了血小板活化后所分泌的各种生长因子、趋化因子和细胞因子等通过促进细胞迁移和增殖,促进血管生成,调控细胞凋亡和细胞存活等多种作用机制,促进受损组织的修复和再生。深入了解血小板参与组织修复的作用机制,有助于了解血小板在临床上的应用,对实现血小板在疾病中的治疗具有重要的临床现实意义。本文就血小板的功能和参与组织修复的作用机制及其临床应用的研究进展作一综述。Platelets are known to play a critical role in thrombosis and hemostasis.However,recent studies demonstrated that beyond their role in thrombosis and hemostasis,platelets are also involved in the regulation of tissue repair and regeneration.Increasing number of studies on the roles of platelets in tissue repair showed that various growth factors,chemokines as well as cytokines secreted from activated platelets regulate injured tissue repair and regeneration with the main mechanisms being through regulation of cell migration,proliferation,and angiogenesis,cell apoptosis and survival.Deeply understanding the molecular mechanism of tissue repair induced by platelets might promote their application in clinic.This review discusses the structure and function of platelets,the mechanism of platelet-induced tissue repair as well as clinical application of platelets.

关 键 词：血小板 组织修复 组织再生 

分 类 号：R331.143[医药卫生—人体生理学]