长链非编码RNA:气道变应性疾病基因治疗新靶点  

lncRNA: an Novel Target for Gene Therapy of Allergic Airway Diseases

作　　者：马志祺 滕尧树[2] 李勇[2] 

机构地区：[1]浙江中医药大学第二临床医学院,硕士研究生杭州310053 [2]杭州市第一人民医院耳鼻咽喉头颈外科,杭州310006

出　　处：《中华临床免疫和变态反应杂志》2016年第3期264-268,共5页Chinese Journal of Allergy & Clinical Immunology

基　　金：杭州市科技发展计划项目(20140733Q05)

摘　　要：随着基因组深度测序工作的完成,大量非编码RNA被发现,其中长链非编码RNA(long non-coding RNA,lncRNA)是最近备受瞩目的哺乳动物转录组重要成员,可在表观遗传水平、转录水平和转录后水平调控基因的表达,广泛参与机体的生理和病理过程。作为多基因调控的气道变应性疾病,lncRNA在其发病过程中的作用正逐步受到关注,并有望成为该病基因治疗的新靶点,本文对lncRNA在气道变应性疾病中的作用及其机制进行综述。With the completion of deep sequencing of the genome, a large number of non-coding RNAs have been found. Long non-coding RNA （lncRNA） is an important member of mammalian transcriptomes which is received much concern recently. They can play important roles in the regulation of gene expression at the levels of epigenetics, transcription and post-transcription, and participate in a series of physiological and pathological processes. It＇s well-known that allergic airway diseases are regulated by multi-genes. LncRNA plays an important role in the pathogenesis of allergic airway diseases and is gradually focused as a novel targets for gene therapy. The roles and its mechanisms of lncRNA in airway allergic diseases were summarized in this review.

关 键 词：长链非编码RNA 气道变应性疾病 基因治疗 机制 

分 类 号：R56[医药卫生—呼吸系统] R450[医药卫生—内科学]