对羟基苯乙腈合成工艺研究  

Synthesis Process Research of 4-hydroxybenzyl Cyanide

作　　者：李广栋[1] 匡少平[2] Li Guangdong Kuang Shaoping(College of Chemistry and Molecular Engineering, Qingdao University of Science＆Technology, Qingdao 266042, China College of Environment Safety Engineering, Qingdao University of Science＆Technology,Qingdao 266042,China)

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266042 [2]青岛科技大学环境与安全工程学院,山东青岛266042

出　　处：《山东化工》2016年第19期8-9,12,共3页Shandong Chemical Industry

摘　　要：本工艺以对羟基苯乙酰胺为原料,经脱水合成目标产物,确定了反应最优条件:以三氯氧磷为脱水剂,在25℃下反应3h,产率93.7%,含量98.7%。对产物进行了1H-NMR、IR结构表征。此工艺原料廉价易得、操作简便、条件温和、副产物少且一步高效的合成目标产物,对实现工业化生产有重大意义。With 4-hydroxybenzeneacetamide as raw material,the target product was synthesized by dehydration reaction,we have identified the optimal conditions of reaction ： with phosphorus oxychloride as dehydrating agent,reaction temperature 25 ℃,reaction time 3 h,the yield of product is 93. 7%. The product structure was characterized by1H-NMR and IR. This process is cheap and easy to obtain raw materials,easy to operate,mild conditions,less by-products and a more efficient synthesis of the target product,it is of great significance to achieve industrial production.

关 键 词：对羟基苯乙酰胺 三氯氧磷 对羟基苯乙腈 脱水剂 

分 类 号：TQ226.61[化学工程—有机化工]