术前静脉泵注右美托咪定对腹腔镜手术血流动力学的影响  

Clinical effect of intravenous pumping of dexmedetomidine in thehemodynamic index prior to the laparoscopic surgery

作　　者：谢力[1] 顾仕贤[1] 

机构地区：[1]南京江北人民医院麻醉科,南京210031

出　　处：《中国处方药》2016年第11期5-7,共3页Journal of China Prescription Drug

摘　　要：目的探讨术前静脉泵注右美托咪定对腹腔镜手术血流动力学的影响。方法将66例需行腹腔镜手术的患者随机分为观察组与对照组各33例,观察组术前给予右美托咪定+丙泊酚+芬太尼+顺式阿曲库铵进行麻醉诱导,对照组采用丙泊酚+芬太尼+顺式阿曲库铵进行麻醉诱导,对比两组患者术中血流动力学指标、术后镇静评分及术后发生不良反应情况的差异。结果在手术过程中,观察组患者各时间点的血流动力学指标:收缩压(SBP)、舒张压(DBP)、心率(HR)均保持稳定,差异无统计学意义(P>0.05),对照组的SBP、DBP、HR在手术过程中具有一定的波动性,各指标较术前均有所增高,差异有统计学意义(P<0.05)。观察组术后镇静评分显著高于对照组,不良反应发生情况少于对照组,差异有统计学意义(P<0.05)。结论术前静脉泵注右美托咪定能够有效维持腹腔镜手术中血流动力学的稳定,在术后发挥良好的镇静效果,减少术后不良反应的发生。Objective To study the clinical effect of intravenous pumping of Dexmedetomidine in the hemodynamic index prior to the laparoscopic surgery.Methods A total of 66 patients who underwent the laparoscopic surgery were enrolled in this study and randomly divided into observation group and control group.Patients in the observation group were given dexmedetomidine ＋ propofol ＋ fentanyl ＋ cisatracurium for anesthesia induction , and patients in the controlgroup were given propofol ＋ fentanyl ＋ cisatracurium for anesthesia induction. The hemodynamic index, sedation score and adverse reactions for two groups wasobserved and recorded. Results At each time period, the hemodynamic index（ SBP, DBP, HR） for observation group was stable（ P 〉 0.05）; the hemodynamicindex（ SBP, DBP, HR） for control group was higher than before（ P 〈 0.05）; the sedation score for observation group was higher than that of control group;the adverse event rate of observation group was lower than that of control group（ P 〈 0.05）. Conclusion Intravenous pumping of Dexmedetomidine during thelaparoscopic surgery was useful to keep the stability of hemodynamics and, played a good sedation effect, which can reduce the adverse event rate.

关 键 词：右美托咪定 腔镜手术 血流动力学 

分 类 号：R614[医药卫生—麻醉学]