内毒素血症致心功能障碍发病机制的研究进展  

Research progress of pathogenesis in endotoxemia-induced cardiac dysfunction

作　　者：肖雄[1] 王玮琦[1,2] 田雯[1,2] 李小强[1] 

机构地区：[1]第四军医大学药学院药理学教研室,西安710032 [2]第四军医大学学员旅,西安710032

出　　处：《西北药学杂志》2016年第6期647-650,共4页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号:81370241;81170107)

摘　　要：目的对内毒素血症致心功能障碍的发病机制进行综述,为内毒素血症相关研究提供参考。方法查阅国内外有关内毒素血症致心功能障碍的文献,总结已有的研究成果与进展。结果内毒素血症致心功能障碍的发病机制可能有Toll样受体的异常表达、体内NO含量的增加、促炎症性因子的过度释放、氧化应激反应、细胞内能量代谢异常、腺苷受体活性降低、心肌细胞凋亡以及心肌细胞内钙离子摄取能力降低等几个方面。结论内毒素血症致心功能障碍的发病机制有待进一步阐释,深入研究将有助于相关疾病的治疗。Objective To summarize the mechanism of endotoxemia-induced cardiac dysfunction,and to provide a reference for the further research.Methods Articles about endotoxemia-induced cardiac dysfunction were summarized.Results The expression of the Toll-like receptors protein,the increase of NO,the delivery of pro-inflammatory cytokines,oxidative stress reaction,abnormal intracellular energy,the decrease of adenosine receptors,myocardial apoptosis and the ability of intake myocardial intracellular calcium decrease were involved in the mechanism of endotoxemia-induced cardiac dysfunction.Conclusion The mechanism of endotoxemia-induced cardiac dysfunction is not yet definite,which needs to be explored more effectively.

关 键 词：心功能障碍 内毒素血症 致病机制 

分 类 号：R972[医药卫生—药品]